First genomic study of puberty yields insights into development and cancer

by Huntsman Cancer InstituteBradley Cairns, Ph.D. Credit: Huntsman Cancer InstituteIn the first-ever genome-scale analysis of the puberty process in humans, researchers at Huntsman Cancer Institute (H

Updated on: December 20,2023 19

First genomic study of puberty yields insights into development and cancer

by Huntsman Cancer InstituteBradley Cairns, Ph.D. Credit: Huntsman Cancer InstituteIn the first-ever genome-scale analysis of the puberty process in humans, researchers at Huntsman Cancer Institute (H

Updated on:December 20,2023 19

Affordable Care Act led to improved treatment of colorectal cancer among young adults

byAmerican Cancer SocietyCredit: CC0 Public DomainAn Affordable Care Act provision that allowed young adults to be covered under their parents' insurance led to a shift to earlier-stage diag

Updated on: December 22,2023 15

Affordable Care Act led to improved treatment of colorectal cancer among young adults

byAmerican Cancer SocietyCredit: CC0 Public DomainAn Affordable Care Act provision that allowed young adults to be covered under their parents' insurance led to a shift to earlier-stage diag

Updated on:December 22,2023 15

Scientists identify multiple cell types that may contribute to treatment resistance in prostate cancer

byeLifeA cell-by-cell tapestry of prostate cancer progression, which the authors created by applying a technique called UMAP to the entire dataset from their study. Credit: Germanos et al. (CC B

Updated on: December 27,2023 8

Scientists identify multiple cell types that may contribute to treatment resistance in prostate cancer

byeLifeA cell-by-cell tapestry of prostate cancer progression, which the authors created by applying a technique called UMAP to the entire dataset from their study. Credit: Germanos et al. (CC B

Updated on:December 27,2023 8

Detailed diagnosis boosts child cancer survival

byCancer Research UK| News6 March 2009More accurate disease classification now means some young children with neuroblastoma will have less intensive treatment with better survival, accordi

Updated on: December 19,2023 8

Detailed diagnosis boosts child cancer survival

byCancer Research UK| News6 March 2009More accurate disease classification now means some young children with neuroblastoma will have less intensive treatment with better survival, accordi

Updated on:December 19,2023 8

Refined method to peer into cancer cells' inner working unlocks the interactome

byJosep Carreras Leukaemia Research InstituteliCHi-C identifies cell types presumably implicated in disease etiology. A Enrichment of GWAS summary statistics at promoter-interacting regions (PIR

Updated on: December 26,2023 10

Refined method to peer into cancer cells' inner working unlocks the interactome

byJosep Carreras Leukaemia Research InstituteliCHi-C identifies cell types presumably implicated in disease etiology. A Enrichment of GWAS summary statistics at promoter-interacting regions (PIR

Updated on:December 26,2023 10

Recruitment mechanism discovered for cancer-associated fibroblasts in common lung cancer

byUniversity of BarcelonaGenetic models to mimic SMAD2/3 alterations in patient-derived ADC-TAFs and SCC-TAFs. a–c, Fold SMAD3 (a) and SMAD2 (b) mRNA and corresponding ratio (c) in primary lung

Updated on: December 21,2023 13

Recruitment mechanism discovered for cancer-associated fibroblasts in common lung cancer

byUniversity of BarcelonaGenetic models to mimic SMAD2/3 alterations in patient-derived ADC-TAFs and SCC-TAFs. a–c, Fold SMAD3 (a) and SMAD2 (b) mRNA and corresponding ratio (c) in primary lung

Updated on:December 21,2023 13

Faster genomics-based diagnosis may accelerate targeted treatment of patients with myeloid neoplasms

byElsevierA: Comparison of clinical assay variant allele fraction (VAF) and Ion Torrent Genexus VAF showed high correlation (r2= 0.98) across a broad range of VAFs, including both in-house

Updated on: December 22,2023 9

Faster genomics-based diagnosis may accelerate targeted treatment of patients with myeloid neoplasms

byElsevierA: Comparison of clinical assay variant allele fraction (VAF) and Ion Torrent Genexus VAF showed high correlation (r2= 0.98) across a broad range of VAFs, including both in-house

Updated on:December 22,2023 9

When cells cycle fast, cancer gets a jumpstart

byYale UniversityCredit: CC0 Public DomainThe progression of cancer has been studied extensively, and the key steps in this journey have been well mapped, at least in some solid tumors: Lesions

Updated on: December 22,2023 17

When cells cycle fast, cancer gets a jumpstart

byYale UniversityCredit: CC0 Public DomainThe progression of cancer has been studied extensively, and the key steps in this journey have been well mapped, at least in some solid tumors: Lesions

Updated on:December 22,2023 17

RET inhibitor selpercatinib demonstrates durable responses in tumor-agnostic population

byUniversity of Texas M. D. Anderson Cancer CenterCredit: Pixabay/CC0 Public DomainThe highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses ac

Updated on: December 17,2023 10

RET inhibitor selpercatinib demonstrates durable responses in tumor-agnostic population

byUniversity of Texas M. D. Anderson Cancer CenterCredit: Pixabay/CC0 Public DomainThe highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses ac

Updated on:December 17,2023 10

Shutting down backup genes leads to cancer remission in mice

by Jim Lynch,University of MichiganAbhinav Achreja, PhD, Research Fellow at the University of Michigan Biomedical Engineering and Deepak Nagrath, Ph.D. Associate Professor of Biomedical Engineer

Updated on: December 22,2023 9

Shutting down backup genes leads to cancer remission in mice

by Jim Lynch,University of MichiganAbhinav Achreja, PhD, Research Fellow at the University of Michigan Biomedical Engineering and Deepak Nagrath, Ph.D. Associate Professor of Biomedical Engineer

Updated on:December 22,2023 9

For some small kidney cancers, freezing is more effective than heat treatment

byWolters Kluwer HealthCredit: Pixabay/CC0 Public DomainFor patients with early-stage renal cell carcinomas (RCCs) that measure between 3 and 4 centimeters, a procedure that destroys the cancer

Updated on: December 21,2023 10

For some small kidney cancers, freezing is more effective than heat treatment

byWolters Kluwer HealthCredit: Pixabay/CC0 Public DomainFor patients with early-stage renal cell carcinomas (RCCs) that measure between 3 and 4 centimeters, a procedure that destroys the cancer

Updated on:December 21,2023 10

AFM24 Plus Atezolizumab Shows Acceptable Safety, Early Activity in EGFR+ Solid Tumors

January 14, 2023Ryan ScottA doublet comprised of the bispecific innate cell engager AFM24 and atezolizumab had a tolerable safety profile and elicited responses in patients with advanced EGFR-expressi

Updated on: October 15,2023 163

AFM24 Plus Atezolizumab Shows Acceptable Safety, Early Activity in EGFR+ Solid Tumors

January 14, 2023Ryan ScottA doublet comprised of the bispecific innate cell engager AFM24 and atezolizumab had a tolerable safety profile and elicited responses in patients with advanced EGFR-expressi

Updated on:October 15,2023 163