Novel immune inhibitor associated with glioma progression

by Melissa Rohman,Northwestern UniversityCAFs are enriched in pediatric HGG relative to LGG and NB. (A) UMAP clustering from 21 pediatric brain samples . (B) The frequency of CAFs is a function

Updated on: March 30,2024

Novel immune inhibitor associated with glioma progression

by Melissa Rohman,Northwestern UniversityCAFs are enriched in pediatric HGG relative to LGG and NB. (A) UMAP clustering from 21 pediatric brain samples . (B) The frequency of CAFs is a function

Updated on:March 30,2024

Study uncovers epigenetic source of resistance to targeted therapy in EGFR-mutant lung cancer

by Dana-Farber Cancer InstituteCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.07.005When lung cancers driven by mutations in the EGFR gene become resistant to osimertinib or othe

Updated on: February 01,2024

Study uncovers epigenetic source of resistance to targeted therapy in EGFR-mutant lung cancer

by Dana-Farber Cancer InstituteCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.07.005When lung cancers driven by mutations in the EGFR gene become resistant to osimertinib or othe

Updated on:February 01,2024

Family of DNA damage–inducing microbial metabolites found in guts of people with IBD

by Bob Yirka , Medical XpressHuman gut microbes isolated from IBD patients produce small-molecule genotoxins. Diverse gut microbes isolated from patients with IBD exhibit direct genotoxicity. M. morga

Updated on: February 03,2024

Family of DNA damage–inducing microbial metabolites found in guts of people with IBD

by Bob Yirka , Medical XpressHuman gut microbes isolated from IBD patients produce small-molecule genotoxins. Diverse gut microbes isolated from patients with IBD exhibit direct genotoxicity. M. morga

Updated on:February 03,2024

Study: GPs managing more skin cancer cases as cost of treatment climbs in Australia

by University of Sydney(A) Proportion of different skin cancer-related conditions managed in general practice, 2000–2016. (B) Management rate per 1,000 encounters of all skin cancer-related condi

Updated on: February 01,2024

Study: GPs managing more skin cancer cases as cost of treatment climbs in Australia

by University of Sydney(A) Proportion of different skin cancer-related conditions managed in general practice, 2000–2016. (B) Management rate per 1,000 encounters of all skin cancer-related condi

Updated on:February 01,2024

Skin cancer rewires its energy systems to spread more efficiently, finds study

by Queen Mary, University of LondonDifferent modes of migration and mitochondrial metabolism.a,bOxygen consumption rate (OCR) from cells embedded in a 3D collagen I matrix (n = 

Updated on: February 18,2024

Skin cancer rewires its energy systems to spread more efficiently, finds study

by Queen Mary, University of LondonDifferent modes of migration and mitochondrial metabolism.a,bOxygen consumption rate (OCR) from cells embedded in a 3D collagen I matrix (n = 

Updated on:February 18,2024

Sniffing out disease with smartphones

by CORDISCredit: CC0 Public DomainGastric cancer, also known as stomach cancer, is the fifth most common cause of cancer-related deaths in Europe. Because of the lack of early signs specifically

Updated on: May 09,2024

Sniffing out disease with smartphones

by CORDISCredit: CC0 Public DomainGastric cancer, also known as stomach cancer, is the fifth most common cause of cancer-related deaths in Europe. Because of the lack of early signs specifically

Updated on:May 09,2024

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

by OncotargetElevated HDAC2 mRNA expression is poorly prognostic in DDLPS. (A) mRNA expression of HDAC2 and disease-free survival (DFS) data from 52 subjects with DDLPS from The Cancer Genome Atlas (T

Updated on: May 11,2024

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

by OncotargetElevated HDAC2 mRNA expression is poorly prognostic in DDLPS. (A) mRNA expression of HDAC2 and disease-free survival (DFS) data from 52 subjects with DDLPS from The Cancer Genome Atlas (T

Updated on:May 11,2024

An AI model reveals how the body's defense system recognizes skin cancer

byUniversity of HelsinkiMicrograph of malignant melanoma. Cytology specimen. Field stain. Credit: Nephron/WikipediaResearchers from the University of Helsinki, HUS Comprehensive Cancer Center, A

Updated on: January 02,2024

An AI model reveals how the body's defense system recognizes skin cancer

byUniversity of HelsinkiMicrograph of malignant melanoma. Cytology specimen. Field stain. Credit: Nephron/WikipediaResearchers from the University of Helsinki, HUS Comprehensive Cancer Center, A

Updated on:January 02,2024

Oncolytic virus treatment produces promising results in patients with triple-negative breast cancer

byH. Lee Moffitt Cancer Center & Research InstituteCredit: Unsplash/CC0 Public DomainTriple-negative breast cancer accounts for approximately 15% of all breast cancer cases. Patients with th

Updated on: January 02,2024

Oncolytic virus treatment produces promising results in patients with triple-negative breast cancer

byH. Lee Moffitt Cancer Center & Research InstituteCredit: Unsplash/CC0 Public DomainTriple-negative breast cancer accounts for approximately 15% of all breast cancer cases. Patients with th

Updated on:January 02,2024

Peripheral surrogates of tumor burden to guide therapeutic strategies for HPV-associated malignancies

by Impact Journals LLCTumor intrinsic and extrinsic factors in the periphery that can serve as proxies of tumor burden. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28487A new review

Updated on: January 22,2024

Peripheral surrogates of tumor burden to guide therapeutic strategies for HPV-associated malignancies

by Impact Journals LLCTumor intrinsic and extrinsic factors in the periphery that can serve as proxies of tumor burden. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28487A new review

Updated on:January 22,2024

Active surveillance feasible for small, low-grade bladder cancer

(HealthDay)—For patients who present with small, low-grade pTa/pT1a recurrent papillary bladder tumors, active surveillance appears to be a reasonable strategy, according to a study published in the F

Updated on: April 07,2024

Active surveillance feasible for small, low-grade bladder cancer

(HealthDay)—For patients who present with small, low-grade pTa/pT1a recurrent papillary bladder tumors, active surveillance appears to be a reasonable strategy, according to a study published in the F

Updated on:April 07,2024

Targeting a unique metabolic pathway might starve pancreatic cancer

by Nancy Fliesler and Andrea Tamayo,Broad Institute of MIT and HarvardMItochondrial staining (red) and nuclear staining (blue) of abnormal pancreatic ducts from a mouse model of human pancreatic

Updated on: February 18,2024

Targeting a unique metabolic pathway might starve pancreatic cancer

by Nancy Fliesler and Andrea Tamayo,Broad Institute of MIT and HarvardMItochondrial staining (red) and nuclear staining (blue) of abnormal pancreatic ducts from a mouse model of human pancreatic

Updated on:February 18,2024