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Diabetes drug shows promise against Parkinson's in clinical study

Diabetes drug shows promise against Parkinson's in clinical study

by By Issam Ahmed and Lucie AubourgPeople play table tennis at the Ping Pong Parkinson initiative in Berlin on April 11, 2023, World Parkinson's Day -- the devastating disorder affects 10 million

Diabetes drug shows promise against Parkinson's in clinical study

by By Issam Ahmed and Lucie AubourgPeople play table tennis at the Ping Pong Parkinson initiative in Berlin on April 11, 2023, World Parkinson's Day -- the devastating disorder affects 10 million
What type of a relationship with an ancient person does a shared DNA fragment imply?

What type of a relationship with an ancient person does a shared DNA fragment imply?

by Shai Carmi and Harald Ringbauer,The ConversationA comparison of one chromosome’s DNA sequence between a 14th-century German Jew and two living people who uploaded their DNA to GEDmatch. Each

What type of a relationship with an ancient person does a shared DNA fragment imply?

by Shai Carmi and Harald Ringbauer,The ConversationA comparison of one chromosome’s DNA sequence between a 14th-century German Jew and two living people who uploaded their DNA to GEDmatch. Each
Scientists uncover key resistance mechanism to Wnt inhibitors in pancreatic and colorectal cancers

Scientists uncover key resistance mechanism to Wnt inhibitors in pancreatic and colorectal cancers

byDuke-NUS Medical SchoolDuke-NUS scientists show that FBXW7-mutant cancers are resistant to Wnt inhibitors by comparing the impact Wnt inhibitor ETC-159 has on cancer cells with and without FBX

Scientists uncover key resistance mechanism to Wnt inhibitors in pancreatic and colorectal cancers

byDuke-NUS Medical SchoolDuke-NUS scientists show that FBXW7-mutant cancers are resistant to Wnt inhibitors by comparing the impact Wnt inhibitor ETC-159 has on cancer cells with and without FBX
New insight into the protein mutations that cause Rett syndrome

New insight into the protein mutations that cause Rett syndrome

byRockefeller UniversityWorking model for normal MeCP2 function on chromatin and its dysregulation in disease. Credit:Nature Structural & Molecular Biology(2024). DOI: 10.1038/s4

New insight into the protein mutations that cause Rett syndrome

byRockefeller UniversityWorking model for normal MeCP2 function on chromatin and its dysregulation in disease. Credit:Nature Structural & Molecular Biology(2024). DOI: 10.1038/s4
Experimental compound extends life in amyotrophic lateral sclerosis mouse model

Experimental compound extends life in amyotrophic lateral sclerosis mouse model

FEBRUARY 6, 2024byUT Southwestern Medical CenterMAP4K interactome and the effect on RANGAP1 subcellular distribution.AWestern-blotting analysis of proteins after proximity labeling i

Experimental compound extends life in amyotrophic lateral sclerosis mouse model

FEBRUARY 6, 2024byUT Southwestern Medical CenterMAP4K interactome and the effect on RANGAP1 subcellular distribution.AWestern-blotting analysis of proteins after proximity labeling i
Protein production glitches in Huntington's disease revealed

Protein production glitches in Huntington's disease revealed

by Shafaq Zia,Whitehead Institute for Biomedical ResearchRNAs with expanded CAG repeats (red) form regions of high concentration in the nucleus (blue) of a cell. Credit: Rachel Anderson/ Whitehe

Protein production glitches in Huntington's disease revealed

by Shafaq Zia,Whitehead Institute for Biomedical ResearchRNAs with expanded CAG repeats (red) form regions of high concentration in the nucleus (blue) of a cell. Credit: Rachel Anderson/ Whitehe
Researchers uncover 'circular logic' of RNAs in Parkinson's disease

Researchers uncover 'circular logic' of RNAs in Parkinson's disease

byBrigham and Women's HospitalScherzer and colleagues laser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison. Then, they used

Researchers uncover 'circular logic' of RNAs in Parkinson's disease

byBrigham and Women's HospitalScherzer and colleagues laser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison. Then, they used
Common dry cleaning chemical linked to Parkinson's

Common dry cleaning chemical linked to Parkinson's

MARCH 14, 2023byUniversity of Rochester Medical CenterCredit: Unsplash/CC0 Public DomainA common and widely used chemical may be fueling the rise of the world's fastest growing brain conditi

Common dry cleaning chemical linked to Parkinson's

MARCH 14, 2023byUniversity of Rochester Medical CenterCredit: Unsplash/CC0 Public DomainA common and widely used chemical may be fueling the rise of the world's fastest growing brain conditi
Meta-analysis of ACE inhibitor–induced angioedema identifies novel risk locus in genome

Meta-analysis of ACE inhibitor–induced angioedema identifies novel risk locus in genome

by Petra Sandow,University Hospital BonnManhattan plot of the metaEURanalysis. The −log10association P values (vertical axis) for all variants of the metaEURanalysis against th

Meta-analysis of ACE inhibitor–induced angioedema identifies novel risk locus in genome

by Petra Sandow,University Hospital BonnManhattan plot of the metaEURanalysis. The −log10association P values (vertical axis) for all variants of the metaEURanalysis against th
A potential method for interrupting the misfolding of tau protein that underlies neurodegenerative disease

A potential method for interrupting the misfolding of tau protein that underlies neurodegenerative disease

by Sonia Fernandez,University of California - Santa BarbaraInvestigation of the effect of VHH Z70 nanobody on jR2R3 P301L-induced tau fibrillization in cells. Credit:Proceedings of the Nat

A potential method for interrupting the misfolding of tau protein that underlies neurodegenerative disease

by Sonia Fernandez,University of California - Santa BarbaraInvestigation of the effect of VHH Z70 nanobody on jR2R3 P301L-induced tau fibrillization in cells. Credit:Proceedings of the Nat
Study shows that the way the brain learns is different from the way that artificial intelligence systems learn

Study shows that the way the brain learns is different from the way that artificial intelligence systems learn

ARTIFICIAL INTELLIGENCEMEDICAL SCIENCESNEUROSCIENCERESEARCHSCIENCEResearchers from theMRC Brain Network Dynamics Unit and Oxford University’sDepartment of Computer Sciencehave set ou

Study shows that the way the brain learns is different from the way that artificial intelligence systems learn

ARTIFICIAL INTELLIGENCEMEDICAL SCIENCESNEUROSCIENCERESEARCHSCIENCEResearchers from theMRC Brain Network Dynamics Unit and Oxford University’sDepartment of Computer Sciencehave set ou