Degrading modified proteins could treat Alzheimer's, other 'undruggable' diseases

by American Chemical SocietyGraphical abstract. Credit:ACS Central Science(2023). DOI: 10.1021/acscentsci.2c01369Certain diseases, including Alzheimer's, are currently considered

Updated on: June 24,2024

Degrading modified proteins could treat Alzheimer's, other 'undruggable' diseases

by American Chemical SocietyGraphical abstract. Credit:ACS Central Science(2023). DOI: 10.1021/acscentsci.2c01369Certain diseases, including Alzheimer's, are currently considered

Updated on:June 24,2024

Overcoming nicotine withdrawal: Clues found in neural mechanisms of the brain

Updated on: March 08,2025

Overcoming nicotine withdrawal: Clues found in neural mechanisms of the brain

Updated on:March 08,2025

Power outage in the brain may be source of Alzheimer's

by Arizona State UniversityMitochondria are membrane-bound organelles present in eukaryotic cells. Their essential role is to supply cells with energy in the form of ATP. Mitochondrial dysfunctio

Updated on: May 18,2024

Power outage in the brain may be source of Alzheimer's

by Arizona State UniversityMitochondria are membrane-bound organelles present in eukaryotic cells. Their essential role is to supply cells with energy in the form of ATP. Mitochondrial dysfunctio

Updated on:May 18,2024

Researchers create a new window on leading genetic cause of Alzheimer's

by Pacific Northwest National LaboratoryWorkflow for molecular characterization of CSF-Lps.Lipoproteins are exchange labeled with a rhodamine-containing phospholipid and size distribution determi

Updated on: March 02,2024

Researchers create a new window on leading genetic cause of Alzheimer's

by Pacific Northwest National LaboratoryWorkflow for molecular characterization of CSF-Lps.Lipoproteins are exchange labeled with a rhodamine-containing phospholipid and size distribution determi

Updated on:March 02,2024

Researchers identify the 'broken gate' causing unstoppable brain signals in severe childhood epilepsy

by Florey Institute of Neuroscience and Mental Health2D transmembrane topology of the wild-type (WT) Nav1.2 channel showing 27 domains DI−DIV and amino acid residues N1662 (cytosolic side of S5DIV) an

Updated on: August 03,2024

Researchers identify the 'broken gate' causing unstoppable brain signals in severe childhood epilepsy

by Florey Institute of Neuroscience and Mental Health2D transmembrane topology of the wild-type (WT) Nav1.2 channel showing 27 domains DI−DIV and amino acid residues N1662 (cytosolic side of S5DIV) an

Updated on:August 03,2024

Depression and dementia in the age of COVID-19

by Donald Weaver,The ConversationMore than half of patients with dementia also suffer from depression. If the depression remains untreated, the associated memory and cognitive problems worsen. C

Updated on: March 30,2024

Depression and dementia in the age of COVID-19

by Donald Weaver,The ConversationMore than half of patients with dementia also suffer from depression. If the depression remains untreated, the associated memory and cognitive problems worsen. C

Updated on:March 30,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on: March 07,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on:March 07,2024

Study finds long-term stroke survival improving, but racial disparities remain

byUniversity of CincinnatiCredit: Pixabay/CC0 Public DomainOverall rates of long-term survival following stroke are improving, but Black individuals experience worse long-term outcomes compared

Updated on: July 17,2024

Study finds long-term stroke survival improving, but racial disparities remain

byUniversity of CincinnatiCredit: Pixabay/CC0 Public DomainOverall rates of long-term survival following stroke are improving, but Black individuals experience worse long-term outcomes compared

Updated on:July 17,2024

Alzheimer's patients are more often hospitalized after initiating antibiotic use

by University of Eastern FinlandCredit: CC0 Public DomainPeople with Alzheimer's disease (AD) are more often hospitalized after antibiotic initiation than people without AD, a new study from

Updated on: March 09,2024

Alzheimer's patients are more often hospitalized after initiating antibiotic use

by University of Eastern FinlandCredit: CC0 Public DomainPeople with Alzheimer's disease (AD) are more often hospitalized after antibiotic initiation than people without AD, a new study from

Updated on:March 09,2024

Virtual reality app offers unique glimpse into life with dementia

by Alzheimer's Research UKCredit: Alzheimer's Research UKAn innovative virtual reality smartphone app – "A Walk Through Dementia" – will launch at a three-day public installatio

Updated on: March 09,2024

Virtual reality app offers unique glimpse into life with dementia

by Alzheimer's Research UKCredit: Alzheimer's Research UKAn innovative virtual reality smartphone app – "A Walk Through Dementia" – will launch at a three-day public installatio

Updated on:March 09,2024

The search for early markers of Alzheimer's Disease

by Ríona Mc Ardle,Public Library of ScienceRegional MRI predictors of MCI-to-dementia progression. Figure courtesy Korolev et al. via PLOS One.This eloquent quote by V.S. Ramachandran expresses

Updated on: February 28,2024

The search for early markers of Alzheimer's Disease

by Ríona Mc Ardle,Public Library of ScienceRegional MRI predictors of MCI-to-dementia progression. Figure courtesy Korolev et al. via PLOS One.This eloquent quote by V.S. Ramachandran expresses

Updated on:February 28,2024

Experience of racism linked with poorer memory and thinking

by Alzheimer's Research UKCredit: Unsplash/CC0 Public DomainResearch presented today (Monday 1 August) at the 2022 Alzheimer's Association International Conference (AAIC) in San Diego acr

Updated on: March 09,2024

Experience of racism linked with poorer memory and thinking

by Alzheimer's Research UKCredit: Unsplash/CC0 Public DomainResearch presented today (Monday 1 August) at the 2022 Alzheimer's Association International Conference (AAIC) in San Diego acr

Updated on:March 09,2024