An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on: March 07,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on:March 07,2024

Midbrain dopamine neurons can retain short-term memories, study shows

byRIKENIdentifying midbrain dopaminergic and GABAergic neurons. Credit:(2024). DOI: 10.7554/eLife.89743.2Dopamine neurons in the midbrain are involved in storing short-term memories—a func

Updated on: July 05,2024

Midbrain dopamine neurons can retain short-term memories, study shows

byRIKENIdentifying midbrain dopaminergic and GABAergic neurons. Credit:(2024). DOI: 10.7554/eLife.89743.2Dopamine neurons in the midbrain are involved in storing short-term memories—a func

Updated on:July 05,2024

Study reveals the possibility of curbing synapse loss in Alzheimer's

by Children's Hospital BostonThis schematic shows how beta-amyloid (Aß) oligomers, the classical complement cascade and microglia work together to induce synapse loss in the pre-plaque Alzhei

Updated on: February 28,2024

Study reveals the possibility of curbing synapse loss in Alzheimer's

by Children's Hospital BostonThis schematic shows how beta-amyloid (Aß) oligomers, the classical complement cascade and microglia work together to induce synapse loss in the pre-plaque Alzhei

Updated on:February 28,2024

Early accumulation of tau in the brain predicts memory decline in Alzheimer's disease

by Karolinska InstitutetHigh accumulation of tau in the brain measured by a PET scanner was the only biomarker that could predict cognitive decline in healthy individuals, people with mild cognit

Updated on: May 18,2024

Early accumulation of tau in the brain predicts memory decline in Alzheimer's disease

by Karolinska InstitutetHigh accumulation of tau in the brain measured by a PET scanner was the only biomarker that could predict cognitive decline in healthy individuals, people with mild cognit

Updated on:May 18,2024

Untangling tau—researchers find a 'druggable target' for treating Alzheimer's disease

by University of California - San DiegoA micrograph by Thomas Deerinck of the National Center for Microscopy and Imaging Research at UC San Diego School of Medicine depicts tangles of tau protein

Updated on: July 01,2024

Untangling tau—researchers find a 'druggable target' for treating Alzheimer's disease

by University of California - San DiegoA micrograph by Thomas Deerinck of the National Center for Microscopy and Imaging Research at UC San Diego School of Medicine depicts tangles of tau protein

Updated on:July 01,2024

Estrogen may offer protection against delirium

by Cedars-Sinai Medical CenterOophorectomy (OVX) and urinary tract infection (UTI)-mediated changes in cleaved caspase-3 (CC3). (A) A schematic of design of a preliminary experiment examining the

Updated on: February 05,2024

Estrogen may offer protection against delirium

by Cedars-Sinai Medical CenterOophorectomy (OVX) and urinary tract infection (UTI)-mediated changes in cleaved caspase-3 (CC3). (A) A schematic of design of a preliminary experiment examining the

Updated on:February 05,2024

How an Alzheimer's-related protein forms plaques

by Leiden UniversityCredit: Leiden UniversityNeurological diseases such as Alzheimer's disease are characterised by aggregates of protein in the brain. The connection of these aggregates to t

Updated on: March 09,2024

How an Alzheimer's-related protein forms plaques

by Leiden UniversityCredit: Leiden UniversityNeurological diseases such as Alzheimer's disease are characterised by aggregates of protein in the brain. The connection of these aggregates to t

Updated on:March 09,2024

Tips for reducing dementia risk

by Susan Barber LindquistCredit: Pixabay/CC0 Public DomainMore than 55 million people worldwide are believed to be living with dementia, according to the World Health Organization. Ronald Petersen, M.

Updated on: June 24,2024

Tips for reducing dementia risk

by Susan Barber LindquistCredit: Pixabay/CC0 Public DomainMore than 55 million people worldwide are believed to be living with dementia, according to the World Health Organization. Ronald Petersen, M.

Updated on:June 24,2024

New review suggests evaluating Tibetan medicinal herb as potential treatment for mild cognitive impairment

by Stephanie Baum , Medical XpressCredit:Frontiers in Pharmacology(2024). DOI: 10.3389/fphar.2024.1484040Within Tibetan medicine, the medicinal herb Terminalia chebula (T. chebula) is well

Updated on: November 07,2024

New review suggests evaluating Tibetan medicinal herb as potential treatment for mild cognitive impairment

by Stephanie Baum , Medical XpressCredit:Frontiers in Pharmacology(2024). DOI: 10.3389/fphar.2024.1484040Within Tibetan medicine, the medicinal herb Terminalia chebula (T. chebula) is well

Updated on:November 07,2024

Mitochondrial DNA fragment losses predict Parkinson's disease before symptoms appear

byUniversity of BarcelonaImage of a fibroblast from a patient with Parkinson's disease. Mitochondria are shown in green and fragments of damaged mitochondria in red. Some of these fragments

Updated on: March 28,2024

Mitochondrial DNA fragment losses predict Parkinson's disease before symptoms appear

byUniversity of BarcelonaImage of a fibroblast from a patient with Parkinson's disease. Mitochondria are shown in green and fragments of damaged mitochondria in red. Some of these fragments

Updated on:March 28,2024

Neuronal heparan sulfates play role in amyloid pathology

(HealthDay)—Neuronal heparan sulfates (HSs) modulate brain amyloid-β (Aβ) clearance and aggregation in a mouse model of Alzheimer's disease (AD), according to an experimental study published in th

Updated on: February 28,2024

Neuronal heparan sulfates play role in amyloid pathology

(HealthDay)—Neuronal heparan sulfates (HSs) modulate brain amyloid-β (Aβ) clearance and aggregation in a mouse model of Alzheimer's disease (AD), according to an experimental study published in th

Updated on:February 28,2024

Investigational Alzheimer's drug improves biomarkers of the disease

by Washington University School of MedicineRandall Bateman, MD, director of the Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), an ongoing international clinical trial to evaluate e

Updated on: April 16,2024

Investigational Alzheimer's drug improves biomarkers of the disease

by Washington University School of MedicineRandall Bateman, MD, director of the Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), an ongoing international clinical trial to evaluate e

Updated on:April 16,2024