Genetic changes differed, increased in people with Alzheimer's disease

by Brigham and Women's HospitalCredit: Public DomainInside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer's disease, these errors—known as somatic mut

Updated on: June 14,2024

Genetic changes differed, increased in people with Alzheimer's disease

by Brigham and Women's HospitalCredit: Public DomainInside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer's disease, these errors—known as somatic mut

Updated on:June 14,2024

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on: April 02,2024

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on:April 02,2024

Older adults with mild cognitive impairment may struggle with everyday decision-making

by Keck School of Medicine of USCCredit: CC0 Public DomainMild cognitive impairment (MCI) is a form of cognitive ability loss that can precede Alzheimer's disease or other types of dementia.

Updated on: June 11,2024

Older adults with mild cognitive impairment may struggle with everyday decision-making

by Keck School of Medicine of USCCredit: CC0 Public DomainMild cognitive impairment (MCI) is a form of cognitive ability loss that can precede Alzheimer's disease or other types of dementia.

Updated on:June 11,2024

Machine-learning program reveals genes responsible for sex-specific differences in Alzheimer's disease progression

by Texas Children's HospitalThe top 98 EAML genes are connected to GWAS genes, dysregulated in AD patients, and capable of separating AD and healthy control samples. Credit:Nature Commu

Updated on: June 11,2024

Machine-learning program reveals genes responsible for sex-specific differences in Alzheimer's disease progression

by Texas Children's HospitalThe top 98 EAML genes are connected to GWAS genes, dysregulated in AD patients, and capable of separating AD and healthy control samples. Credit:Nature Commu

Updated on:June 11,2024

Researchers investigate roles of orexin in energy metabolism during sleep in humans

byUniversity of TsukubaEEG record during indirect calorimetry using a whole room metabolic chamber. Credit: University of TsukubaOrexin, named after its role in feeding regulation, is a potent e

Updated on: July 06,2024

Researchers investigate roles of orexin in energy metabolism during sleep in humans

byUniversity of TsukubaEEG record during indirect calorimetry using a whole room metabolic chamber. Credit: University of TsukubaOrexin, named after its role in feeding regulation, is a potent e

Updated on:July 06,2024

Neural activity study shows the brain processes direct speech and its echo separately

byPublic Library of ScienceSpeech processing in an echoic environment. Credit: Jiaxin Gao (CC-BY 4.0, creativecommons.org/licenses/by/4.0/)Echoes can make speech harder to understand, and tuning

Updated on: March 13,2024

Neural activity study shows the brain processes direct speech and its echo separately

byPublic Library of ScienceSpeech processing in an echoic environment. Credit: Jiaxin Gao (CC-BY 4.0, creativecommons.org/licenses/by/4.0/)Echoes can make speech harder to understand, and tuning

Updated on:March 13,2024

Dementia metaphors help describe the condition, but can also perpetuate stigma and hinder treatment

by Jasmine Mah and Kaitlin Sibbald,The ConversationCredit: AI-generated imageHalf a million Canadians are living with dementiaandone in five Canadians has cared for someone with deme

Updated on: May 06,2024

Dementia metaphors help describe the condition, but can also perpetuate stigma and hinder treatment

by Jasmine Mah and Kaitlin Sibbald,The ConversationCredit: AI-generated imageHalf a million Canadians are living with dementiaandone in five Canadians has cared for someone with deme

Updated on:May 06,2024

How COVID-19 might increase risk of memory loss and cognitive decline

by Natalie C. Tronson,The ConversationCredit: CC0 Public DomainOf all frightening ways that the SARS-COV-2 virus affects the body, one of the more insidious is the effect of COVID-19 on the brai

Updated on: March 30,2024

How COVID-19 might increase risk of memory loss and cognitive decline

by Natalie C. Tronson,The ConversationCredit: CC0 Public DomainOf all frightening ways that the SARS-COV-2 virus affects the body, one of the more insidious is the effect of COVID-19 on the brai

Updated on:March 30,2024

Halloween can be a scary time for people with dementia. Here's how to help

by Cara MurezWhen there are suddenly creepy decorations and lots of knocks at the door from strangers, Halloween can be frightening for someone living withdementia.It is possible to keep a loved

Updated on: May 26,2024

Halloween can be a scary time for people with dementia. Here's how to help

by Cara MurezWhen there are suddenly creepy decorations and lots of knocks at the door from strangers, Halloween can be frightening for someone living withdementia.It is possible to keep a loved

Updated on:May 26,2024

Single-cell dissection of Alzheimer's vascular changes across six brain regions

by Rachel Gordon, MIT Computer Science & Artificial Intelligence LabExperimental validation of adDEGs. a. Chromogenic RNAscope for ABCC9 and SLC6A1. Prefrontal cortex brain sections (n = 4 for AD

Updated on: April 20,2024

Single-cell dissection of Alzheimer's vascular changes across six brain regions

by Rachel Gordon, MIT Computer Science & Artificial Intelligence LabExperimental validation of adDEGs. a. Chromogenic RNAscope for ABCC9 and SLC6A1. Prefrontal cortex brain sections (n = 4 for AD

Updated on:April 20,2024

Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on: July 25,2024

Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on:July 25,2024

Insulin resistance in shift workers not affected by melatonin treatment, finds study

by University of SurreyTime course of serum glucose and insulin concentrations during oral glucose tolerance testing in night shift workers at baseline, after 12 weeks, and after 24 weeks as comp

Updated on: March 05,2024

Insulin resistance in shift workers not affected by melatonin treatment, finds study

by University of SurreyTime course of serum glucose and insulin concentrations during oral glucose tolerance testing in night shift workers at baseline, after 12 weeks, and after 24 weeks as comp

Updated on:March 05,2024