Eli Lilly changes outcome goals in Alzheimer's drug study

by Linda A. JohnsonEli Lilly said Tuesday that it's changed the outcome goals for a late-stage patient study of its closely watched experimental drug for Alzheimer's disease, solanezumab.The E

Updated on: February 28,2024 13

Eli Lilly changes outcome goals in Alzheimer's drug study

by Linda A. JohnsonEli Lilly said Tuesday that it's changed the outcome goals for a late-stage patient study of its closely watched experimental drug for Alzheimer's disease, solanezumab.The E

Updated on:February 28,2024 13

Racial differences in Alzheimer's disease unveiled

by Washington University School of MedicineCredit: CC0 Public DomainAfrican-Americans may be twice as likely as Caucasian Americans to develop Alzheimer's disease, but nobody knows why becaus

Updated on: April 08,2024 17

Racial differences in Alzheimer's disease unveiled

by Washington University School of MedicineCredit: CC0 Public DomainAfrican-Americans may be twice as likely as Caucasian Americans to develop Alzheimer's disease, but nobody knows why becaus

Updated on:April 08,2024 17

ssResearchers identify key steps to toxic protein accumulation in Alzheimer's and other diseases

by Tamara Bhandari,Washington University School of Medicine in St. LouisStress granules (red) fill stem cell-derived neurons (nuclei shown in blue) from a person with a mutation in the tau gene.

Updated on: March 02,2024 18

ssResearchers identify key steps to toxic protein accumulation in Alzheimer's and other diseases

by Tamara Bhandari,Washington University School of Medicine in St. LouisStress granules (red) fill stem cell-derived neurons (nuclei shown in blue) from a person with a mutation in the tau gene.

Updated on:March 02,2024 18

Survey uncovers pandemic's complex impact on people living with dementia and their families

by Kerry Blackadar,University of British ColumbiaCredit:Huy Phan/UnsplashCOVID-19 has been especially challenging for people living with dementia, their families and caregivers, confirms a

Updated on: May 22,2024 6

Survey uncovers pandemic's complex impact on people living with dementia and their families

by Kerry Blackadar,University of British ColumbiaCredit:Huy Phan/UnsplashCOVID-19 has been especially challenging for people living with dementia, their families and caregivers, confirms a

Updated on:May 22,2024 6

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on: January 11,2024 10

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on:January 11,2024 10

Gut could sound early warning alarm for motor neuron disease

by University of AberdeenCredit: Pixabay/CC0 Public DomainThe same proteins thought to contribute to motor neuron disease can be found in the gut many years before any brain symptoms occur, a new

Updated on: February 03,2024 11

Gut could sound early warning alarm for motor neuron disease

by University of AberdeenCredit: Pixabay/CC0 Public DomainThe same proteins thought to contribute to motor neuron disease can be found in the gut many years before any brain symptoms occur, a new

Updated on:February 03,2024 11

Brain cell death in ALS, dementia tied to loss of key biochemical transport structure in nucleus

by Vanessa McMains,Johns Hopkins University(Top) The nuclear pore protein Pom121 in healthy brain cells. (Bottom) Brain cells with an ALS/dementia genetic mutation have less of the nuclear pore

Updated on: June 14,2024 6

Brain cell death in ALS, dementia tied to loss of key biochemical transport structure in nucleus

by Vanessa McMains,Johns Hopkins University(Top) The nuclear pore protein Pom121 in healthy brain cells. (Bottom) Brain cells with an ALS/dementia genetic mutation have less of the nuclear pore

Updated on:June 14,2024 6

Study opens the door to earlier diagnosis and potential treatment for Alzheimer's disease

by Aarhus UniversityLarge Aβ Agg [+] MCI patients display lower AD-like brain pathology than large Aβ Agg [-] MCI.a18F-FTP PET uptake in each group at baseline, two-year follow-up, an

Updated on: March 19,2024 13

Study opens the door to earlier diagnosis and potential treatment for Alzheimer's disease

by Aarhus UniversityLarge Aβ Agg [+] MCI patients display lower AD-like brain pathology than large Aβ Agg [-] MCI.a18F-FTP PET uptake in each group at baseline, two-year follow-up, an

Updated on:March 19,2024 13

Are the olfactory responses of patients in a coma or vegetative state signs of consciousness?

by Ingrid Fadelli , Medical XpressBehavioral results and global connectivity among HCs, ORES, and N-ORES. (A) The proportion of olfactory response among MCS and VS/UWS patients. A relationship was obs

Updated on: February 03,2024 13

Are the olfactory responses of patients in a coma or vegetative state signs of consciousness?

by Ingrid Fadelli , Medical XpressBehavioral results and global connectivity among HCs, ORES, and N-ORES. (A) The proportion of olfactory response among MCS and VS/UWS patients. A relationship was obs

Updated on:February 03,2024 13

Adults with Alzheimer's risk factors show subtle alterations in brain networks despite normal cognition

by Jason Clement,McGill UniversityPET scan of a human brain with Alzheimer's disease. Credit: public domainResearchers at McGill University and the Douglas Mental Health University Institute

Updated on: June 07,2024 7

Adults with Alzheimer's risk factors show subtle alterations in brain networks despite normal cognition

by Jason Clement,McGill UniversityPET scan of a human brain with Alzheimer's disease. Credit: public domainResearchers at McGill University and the Douglas Mental Health University Institute

Updated on:June 07,2024 7

It is not clear whether new Alzheimer's drugs will make a difference at a population level, say researchers

byUniversity of CambridgeCredit: CC0 Public DomainCambridge researchers have cast doubt on whether new amyloid immunotherapy drugs will have the desired effect of significantly reducing the impa

Updated on: August 08,2024 0

It is not clear whether new Alzheimer's drugs will make a difference at a population level, say researchers

byUniversity of CambridgeCredit: CC0 Public DomainCambridge researchers have cast doubt on whether new amyloid immunotherapy drugs will have the desired effect of significantly reducing the impa

Updated on:August 08,2024 0

Could a breakdown in the brain's networks allow infections to contribute to Alzheimer's disease?

by Drexel UniversityCartoon of the LDA algorithm. Credit:Frontiers in Cellular and Infection Microbiology(2023). DOI: 10.3389/fcimb.2023.1123228The human microbiome includes the genet

Updated on: March 02,2024 20

Could a breakdown in the brain's networks allow infections to contribute to Alzheimer's disease?

by Drexel UniversityCartoon of the LDA algorithm. Credit:Frontiers in Cellular and Infection Microbiology(2023). DOI: 10.3389/fcimb.2023.1123228The human microbiome includes the genet

Updated on:March 02,2024 20