Bench-to-bedside drug design could lead to new Alzheimer's disease treatments

by University of GlasgowCredit: CC0 Public DomainAn international team of scientists and pharmaceutical collaborators has made a breakthrough "bench to bedside" discovery, ten years in

Updated on: May 13,2024

Bench-to-bedside drug design could lead to new Alzheimer's disease treatments

by University of GlasgowCredit: CC0 Public DomainAn international team of scientists and pharmaceutical collaborators has made a breakthrough "bench to bedside" discovery, ten years in

Updated on:May 13,2024

Could a computer diagnose Alzheimer's disease and dementia?

by Gina Mantica,Boston UniversityCredit: Pixabay/CC0 Public DomainIt takes a lot of time—and money—to diagnose Alzheimer's disease. After running lengthy in-person neuropsychological exams,

Updated on: June 18,2024

Could a computer diagnose Alzheimer's disease and dementia?

by Gina Mantica,Boston UniversityCredit: Pixabay/CC0 Public DomainIt takes a lot of time—and money—to diagnose Alzheimer's disease. After running lengthy in-person neuropsychological exams,

Updated on:June 18,2024

Need for formal bereavement support in dementia care is largely underestimated

by University College LondonCredit: Unsplash/CC0 Public DomainThe need for grief counseling in dementia care may be substantially underestimated, according to new research led by a UCL academic.T

Updated on: May 08,2024

Need for formal bereavement support in dementia care is largely underestimated

by University College LondonCredit: Unsplash/CC0 Public DomainThe need for grief counseling in dementia care may be substantially underestimated, according to new research led by a UCL academic.T

Updated on:May 08,2024

Different anxiety-related behaviors are mediated by different neural circuits and molecular mechanisms

by Zhejiang UniversityDRNvGluT3∩5-HT→BAPyrand DRNvGluT3∩5-HT→BAPVpathways differentially regulate anxiety-related behaviors. Credit: Zhejiang UniversityAnxiety is a common negative emotion

Updated on: February 03,2024

Different anxiety-related behaviors are mediated by different neural circuits and molecular mechanisms

by Zhejiang UniversityDRNvGluT3∩5-HT→BAPyrand DRNvGluT3∩5-HT→BAPVpathways differentially regulate anxiety-related behaviors. Credit: Zhejiang UniversityAnxiety is a common negative emotion

Updated on:February 03,2024

A new mechanism for crossing the blood–brain barrier

by Lori Dajose,California Institute of TechnologyCA-IV is required for the CNS potency of Car4-dependent AAV. (A) Immunostaining for CA-IV in the brains of WT/WT and KO/KO Car4 mice. Magnified r

Updated on: February 05,2024

A new mechanism for crossing the blood–brain barrier

by Lori Dajose,California Institute of TechnologyCA-IV is required for the CNS potency of Car4-dependent AAV. (A) Immunostaining for CA-IV in the brains of WT/WT and KO/KO Car4 mice. Magnified r

Updated on:February 05,2024

How astrocytes and perineuronal nets cooperate to sustain synaptic homeostasis

by Ingrid Fadelli , Medical XpressConfocal micrographs showing close association between Perineuronal nets (magenta) and astrocytes (green) in mouse cerebral cortex. Credit: Bhanu TewariSynapses are s

Updated on: August 08,2024

How astrocytes and perineuronal nets cooperate to sustain synaptic homeostasis

by Ingrid Fadelli , Medical XpressConfocal micrographs showing close association between Perineuronal nets (magenta) and astrocytes (green) in mouse cerebral cortex. Credit: Bhanu TewariSynapses are s

Updated on:August 08,2024

Why some types of music make people want to dance more than others

by Bob Yirka , Medical XpressTwelve 8-s melodies with a 2-Hz beat were created. For each melody, three variants were designed to vary the level of rhythmic predictability (degree of syncopation) while

Updated on: March 30,2024

Why some types of music make people want to dance more than others

by Bob Yirka , Medical XpressTwelve 8-s melodies with a 2-Hz beat were created. For each melody, three variants were designed to vary the level of rhythmic predictability (degree of syncopation) while

Updated on:March 30,2024

Power of light and oxygen clears Alzheimer's disease protein in live mice

by University of TokyoCredit: Unsplash/CC0 Public DomainA small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the b

Updated on: June 05,2024

Power of light and oxygen clears Alzheimer's disease protein in live mice

by University of TokyoCredit: Unsplash/CC0 Public DomainA small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the b

Updated on:June 05,2024

Understanding the how and why of preterm brain injury

by Rob Clancy,Hudson Institute of Medical ResearchRepresentative images of NeuN- and MAP2-positive cells in the cortical gray matter (cortex; Layer V) and caudate. Scale bar represents 50μ

Updated on: September 23,2024

Understanding the how and why of preterm brain injury

by Rob Clancy,Hudson Institute of Medical ResearchRepresentative images of NeuN- and MAP2-positive cells in the cortical gray matter (cortex; Layer V) and caudate. Scale bar represents 50μ

Updated on:September 23,2024

How different flavors of inhibition save the day

by Irina Epstein,Max Planck SocietyCredit: Pixabay/CC0 Public DomainDuring development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibit

Updated on: February 03,2024

How different flavors of inhibition save the day

by Irina Epstein,Max Planck SocietyCredit: Pixabay/CC0 Public DomainDuring development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibit

Updated on:February 03,2024

Alzheimer's linked to the brain's 'garbage disposal service'

by Andrew Spence, The LeadPET scan of a human brain with Alzheimer's disease. Credit: public domainResearchers in South Australia have found a genetic link between Alzheimer's disease and the

Updated on: April 25,2024

Alzheimer's linked to the brain's 'garbage disposal service'

by Andrew Spence, The LeadPET scan of a human brain with Alzheimer's disease. Credit: public domainResearchers in South Australia have found a genetic link between Alzheimer's disease and the

Updated on:April 25,2024

World's first collection of brain metastasis living samples will help treat each patient with the most effective therapy

byThe Spanish National Cancer Research CentreSample prepared, classified and conserved at the CNIO Biobank. Credit: Laura M. Lombardía / CNIOAt 18 Spanish hospitals, when a patient with brain me

Updated on: January 12,2024

World's first collection of brain metastasis living samples will help treat each patient with the most effective therapy

byThe Spanish National Cancer Research CentreSample prepared, classified and conserved at the CNIO Biobank. Credit: Laura M. Lombardía / CNIOAt 18 Spanish hospitals, when a patient with brain me

Updated on:January 12,2024