A new breakthrough in Alzheimer's disease research: Visualizing reactive astrocyte-neuron interaction

by Institute for Basic ScienceFig. 1. Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acet

Updated on: April 16,2024

A new breakthrough in Alzheimer's disease research: Visualizing reactive astrocyte-neuron interaction

by Institute for Basic ScienceFig. 1. Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acet

Updated on:April 16,2024

Insights on the link between chronic stress and Alzheimer's disease

by WileyCredit: Pixabay/CC0 Public DomainChronic psychosocial stress—which involves a pathway called the hypothalamic-pituitary-adrenal axis (HPA axis)—may contribute to the development of Alzhei

Updated on: June 05,2024

Insights on the link between chronic stress and Alzheimer's disease

by WileyCredit: Pixabay/CC0 Public DomainChronic psychosocial stress—which involves a pathway called the hypothalamic-pituitary-adrenal axis (HPA axis)—may contribute to the development of Alzhei

Updated on:June 05,2024

Early-life stress can disrupt maturation of brain's reward circuits, promoting disorders

by University of California, IrvineA projection of CRH/GABA neurons in the medial BLA to the medial NAc shell.a–cRetrograde tracing of CRH+neuronal inputs to medial NAc shell of

Updated on: March 26,2024

Early-life stress can disrupt maturation of brain's reward circuits, promoting disorders

by University of California, IrvineA projection of CRH/GABA neurons in the medial BLA to the medial NAc shell.a–cRetrograde tracing of CRH+neuronal inputs to medial NAc shell of

Updated on:March 26,2024

Researchers develop new brain network modeling tools to advance Alzheimer's disease research

by Indiana University School of MedicineCredit: CC0 Public DomainIndiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools—previously dev

Updated on: February 24,2024

Researchers develop new brain network modeling tools to advance Alzheimer's disease research

by Indiana University School of MedicineCredit: CC0 Public DomainIndiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools—previously dev

Updated on:February 24,2024

Leading AI chatbots show dementia-like cognitive decline in tests, raising questions about their future in medicine

byBritish Medical JournalCredit: Pixabay/CC0 Public DomainAlmost all leading large language models or "chatbots" show signs of mild cognitive impairment in tests widely used to spot ea

Updated on: January 18,2025

Leading AI chatbots show dementia-like cognitive decline in tests, raising questions about their future in medicine

byBritish Medical JournalCredit: Pixabay/CC0 Public DomainAlmost all leading large language models or "chatbots" show signs of mild cognitive impairment in tests widely used to spot ea

Updated on:January 18,2025

Treatment of metabolic dysfunction could be a potential therapy for Alzheimer's disease

by Yale-NUS CollegeCredit: CC0 Public DomainA team of researchers led by Yale-NUS College has found evidence that metabolic dysfunction is a primary cause of Alzheimer's disease.Alzheimer&#39

Updated on: May 20,2024

Treatment of metabolic dysfunction could be a potential therapy for Alzheimer's disease

by Yale-NUS CollegeCredit: CC0 Public DomainA team of researchers led by Yale-NUS College has found evidence that metabolic dysfunction is a primary cause of Alzheimer's disease.Alzheimer&#39

Updated on:May 20,2024

Risk factors for Parkinson's disease: Study proves the protective function of the RIT2 gene

by Eurac ResearchIn vivo aSyn overexpression increases endogenous LRRK2 activity, which is prevented by Rit2 co-expression.aPLA analysis of AAV-GFP, AAV-A53T-aSyn and AAV-A53T-aSyn + AAV-R

Updated on: June 17,2024

Risk factors for Parkinson's disease: Study proves the protective function of the RIT2 gene

by Eurac ResearchIn vivo aSyn overexpression increases endogenous LRRK2 activity, which is prevented by Rit2 co-expression.aPLA analysis of AAV-GFP, AAV-A53T-aSyn and AAV-A53T-aSyn + AAV-R

Updated on:June 17,2024

Study finds non-immune brain cells can acquire immune memory, may drive CNS pathologies like multiple sclerosis

byBrigham and Women’s Hospitalp300 promotes astrocyte epigenetic memory in EAE.a, Immunostaining (left) and quantification (right) of H3K27ac+and p300+astrocytes in mice with o

Updated on: March 28,2024

Study finds non-immune brain cells can acquire immune memory, may drive CNS pathologies like multiple sclerosis

byBrigham and Women’s Hospitalp300 promotes astrocyte epigenetic memory in EAE.a, Immunostaining (left) and quantification (right) of H3K27ac+and p300+astrocytes in mice with o

Updated on:March 28,2024

How sensory neurons impact the gut

by The Scripps Research InstituteResearchers showed that PIEZO2 receptors in sensory neurons control the rate of gut transit. In this fluorescently stained microscopy image, nerve endings stemmin

Updated on: June 20,2024

How sensory neurons impact the gut

by The Scripps Research InstituteResearchers showed that PIEZO2 receptors in sensory neurons control the rate of gut transit. In this fluorescently stained microscopy image, nerve endings stemmin

Updated on:June 20,2024

Sounding the alarm on a future Alzheimer's disease epidemic

by Carla Denly,University of California, Los AngelesWe're living longer. The number of U.S. adults 65 and older—roughly 40 million as of the 2010 census—is expected to nearly double to 71 mi

Updated on: February 27,2024

Sounding the alarm on a future Alzheimer's disease epidemic

by Carla Denly,University of California, Los AngelesWe're living longer. The number of U.S. adults 65 and older—roughly 40 million as of the 2010 census—is expected to nearly double to 71 mi

Updated on:February 27,2024

How different flavors of inhibition save the day

by Irina Epstein,Max Planck SocietyCredit: Pixabay/CC0 Public DomainDuring development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibit

Updated on: February 03,2024

How different flavors of inhibition save the day

by Irina Epstein,Max Planck SocietyCredit: Pixabay/CC0 Public DomainDuring development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibit

Updated on:February 03,2024

Practical self-help guide for people with dementia

by University of ExeterCredit: CC0 Public DomainA free self-help guide is now available to support people diagnosed with dementia to achieve their goals to enjoy daily activities and independent

Updated on: May 08,2024

Practical self-help guide for people with dementia

by University of ExeterCredit: CC0 Public DomainA free self-help guide is now available to support people diagnosed with dementia to achieve their goals to enjoy daily activities and independent

Updated on:May 08,2024