Cell-type-specific genetic risk contributes to distinct stages of Alzheimer's disease progression, finds study

by Brigham and Women's HospitalCell-type-specific Alzheimer’s disease polygenic risk scores (ADPRS).aA schematic of cell-type-specific PRS derivation.bAn UpSetR plot o

Updated on: February 24,2024 17

Cell-type-specific genetic risk contributes to distinct stages of Alzheimer's disease progression, finds study

by Brigham and Women's HospitalCell-type-specific Alzheimer’s disease polygenic risk scores (ADPRS).aA schematic of cell-type-specific PRS derivation.bAn UpSetR plot o

Updated on:February 24,2024 17

More seniors may have undiagnosed dementia than previously thought

by University of MichiganCredit: CC0 Public DomainOnly 1 in 10 older adults in a large national survey who were found to have cognitive impairment consistent with dementia reported a formal medic

Updated on: June 05,2024 3

More seniors may have undiagnosed dementia than previously thought

by University of MichiganCredit: CC0 Public DomainOnly 1 in 10 older adults in a large national survey who were found to have cognitive impairment consistent with dementia reported a formal medic

Updated on:June 05,2024 3

Analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

by Liu Jia,Chinese Academy of SciencesStable real-time analysis of optical imaging of large-scale neuronal activities. a, FX design-based real-time analysis system for large-scale imaging, in co

Updated on: March 19,2024 17

Analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

by Liu Jia,Chinese Academy of SciencesStable real-time analysis of optical imaging of large-scale neuronal activities. a, FX design-based real-time analysis system for large-scale imaging, in co

Updated on:March 19,2024 17

New target for Alzheimer's therapies found

by German Center for Neurodegenerative DiseasesMedin interacts directly with amyloid-β, promoting its aggregation.a, Immuno-electron microscopy of MFG-E8 (or fragment) staining in cortical

Updated on: May 28,2024 7

New target for Alzheimer's therapies found

by German Center for Neurodegenerative DiseasesMedin interacts directly with amyloid-β, promoting its aggregation.a, Immuno-electron microscopy of MFG-E8 (or fragment) staining in cortical

Updated on:May 28,2024 7

Specialized motor neuron region affected in amyotrophic lateral sclerosis, new study finds

byKing's College LondonCredit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.113509A new study,publishedinCell Reports, reports a novel mechanism behind dysregu

Updated on: April 09,2024 0

Specialized motor neuron region affected in amyotrophic lateral sclerosis, new study finds

byKing's College LondonCredit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.113509A new study,publishedinCell Reports, reports a novel mechanism behind dysregu

Updated on:April 09,2024 0

Researchers map converging trajectories of cognitive development through adolescence

byUniversity of PittsburghScaled domain general executive function scores generate reproducible adolescent growth charts across datasets and tasks. Accuracy (A) and latency (B) composite (z scor

Updated on: January 12,2024 6

Researchers map converging trajectories of cognitive development through adolescence

byUniversity of PittsburghScaled domain general executive function scores generate reproducible adolescent growth charts across datasets and tasks. Accuracy (A) and latency (B) composite (z scor

Updated on:January 12,2024 6

Better than a hole in the head: Modernizing intracranial pressure sensing methods

by Sara Vaccar,Carnegie Mellon UniversityCredit: Carnegie Mellon UniversityJust as blood pressure informs heart health, intracranial pressure (ICP) helps indicate brain health. ICP sensing is th

Updated on: February 03,2024 19

Better than a hole in the head: Modernizing intracranial pressure sensing methods

by Sara Vaccar,Carnegie Mellon UniversityCredit: Carnegie Mellon UniversityJust as blood pressure informs heart health, intracranial pressure (ICP) helps indicate brain health. ICP sensing is th

Updated on:February 03,2024 19

Alzheimer's: New gene may drive earliest brain changes

by Columbia University Irving Medical CenterPET scan of a human brain with Alzheimer's disease. Credit: public domainA newly discovered Alzheimer's gene may drive the first appearance of

Updated on: April 20,2024 13

Alzheimer's: New gene may drive earliest brain changes

by Columbia University Irving Medical CenterPET scan of a human brain with Alzheimer's disease. Credit: public domainA newly discovered Alzheimer's gene may drive the first appearance of

Updated on:April 20,2024 13

Calcium channel blockers may be effective in treating memory loss associated with Alzheimer's

by University of BristolTreating diseased brain cells with calcium channel blockers. Credit: University of BristolAlzheimer's disease (AD) is the most common cause of dementia but the changes

Updated on: June 04,2024 8

Calcium channel blockers may be effective in treating memory loss associated with Alzheimer's

by University of BristolTreating diseased brain cells with calcium channel blockers. Credit: University of BristolAlzheimer's disease (AD) is the most common cause of dementia but the changes

Updated on:June 04,2024 8

Shorter telomeres point to increased Alzheimer's risk

by Kim Krieger,University of ConnecticutHuman chromosomes (grey) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASAShort telomeres in midlife are associated with a higher risk of develo

Updated on: May 22,2024 7

Shorter telomeres point to increased Alzheimer's risk

by Kim Krieger,University of ConnecticutHuman chromosomes (grey) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASAShort telomeres in midlife are associated with a higher risk of develo

Updated on:May 22,2024 7

More Alzheimer's drug trial failures: are researchers on the wrong track?

by Dennis Thompson, Healthday Reporter(HealthDay)—Amyloid beta has long been a prime suspect in Alzheimer's disease, since abnormal levels of the protein form disruptive plaques between patients&#

Updated on: June 05,2024 8

More Alzheimer's drug trial failures: are researchers on the wrong track?

by Dennis Thompson, Healthday Reporter(HealthDay)—Amyloid beta has long been a prime suspect in Alzheimer's disease, since abnormal levels of the protein form disruptive plaques between patients&#

Updated on:June 05,2024 8

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS disease

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS diseasebyTokyo Medical and Dental UniversityWe designed and synthesized both a conventional A

Updated on: May 30,2024 0

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS disease

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS diseasebyTokyo Medical and Dental UniversityWe designed and synthesized both a conventional A

Updated on:May 30,2024 0