Another angle on Alzheimer's: CSF, proteomics, and metabolic enzymes

by Nancy Fliesler,Children's Hospital BostonGraphical abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101005Currently there are no objective, easily assess

Updated on: April 23,2024

Another angle on Alzheimer's: CSF, proteomics, and metabolic enzymes

by Nancy Fliesler,Children's Hospital BostonGraphical abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101005Currently there are no objective, easily assess

Updated on:April 23,2024

Study shows DNA organization can influence the growth of deadly brain tumors in response to neuronal signals

by Gustav Löfgren,Swedish Research CouncilGene expression changes common to all four GB subtypes relate to synapse organization, glutamatergic synapses and chromatin binding (OPCs: oligodendrocy

Updated on: January 11,2024

Study shows DNA organization can influence the growth of deadly brain tumors in response to neuronal signals

by Gustav Löfgren,Swedish Research CouncilGene expression changes common to all four GB subtypes relate to synapse organization, glutamatergic synapses and chromatin binding (OPCs: oligodendrocy

Updated on:January 11,2024

Neural probe achieves brain-wide neuronal activity recording in macaque brain

byPeking UniversityRecording in an awake rhesus macaque under a fixation-saccade task. a, Schematics showing the setup of the recording. b, Schematics showing the fixation-saccade task. c, Spati

Updated on: July 08,2024

Neural probe achieves brain-wide neuronal activity recording in macaque brain

byPeking UniversityRecording in an awake rhesus macaque under a fixation-saccade task. a, Schematics showing the setup of the recording. b, Schematics showing the fixation-saccade task. c, Spati

Updated on:July 08,2024

Identifying typical patterns in the progression towards Alzheimer's disease

by University of MontrealHow the brain progresses from mild cognitive impairment (MCI) to Alzheimer's-type dementia has been an enigma for the scientific community. However, a recent study by

Updated on: February 26,2024

Identifying typical patterns in the progression towards Alzheimer's disease

by University of MontrealHow the brain progresses from mild cognitive impairment (MCI) to Alzheimer's-type dementia has been an enigma for the scientific community. However, a recent study by

Updated on:February 26,2024

Poor cognitive performance predicts impairment in activities of daily living years later

by University of California - San DiegoCredit: CC0 Public DomainSubtle differences in cognition may help identify individuals at risk for becoming dependent years later upon others to complete da

Updated on: June 24,2024

Poor cognitive performance predicts impairment in activities of daily living years later

by University of California - San DiegoCredit: CC0 Public DomainSubtle differences in cognition may help identify individuals at risk for becoming dependent years later upon others to complete da

Updated on:June 24,2024

Risk factors of Alzheimer's disease and metabolic syndrome can accumulate in childhood

byUniversity of Eastern FinlandCredit: CC0 Public DomainGenetic predisposition to Alzheimer's disease is linked to an increased risk of cardiometabolic disorders present in childhood, a new

Updated on: April 08,2024

Risk factors of Alzheimer's disease and metabolic syndrome can accumulate in childhood

byUniversity of Eastern FinlandCredit: CC0 Public DomainGenetic predisposition to Alzheimer's disease is linked to an increased risk of cardiometabolic disorders present in childhood, a new

Updated on:April 08,2024

Molecular mechanism behind HIV-associated dementia revealed

by Will Doss,Northwestern UniversityThe interaction between APP (red) and GAG (green) in the cell. Credit: Northwestern UniversityFor the first time, scientists have identified and inhibited a m

Updated on: March 30,2024

Molecular mechanism behind HIV-associated dementia revealed

by Will Doss,Northwestern UniversityThe interaction between APP (red) and GAG (green) in the cell. Credit: Northwestern UniversityFor the first time, scientists have identified and inhibited a m

Updated on:March 30,2024

Aβ43 generation in familial Alzheimer's disease: New insights into disease onset

by Doshisha UniversityIn this study, γ-secretase was extracted from wild type (WT) cells and cells carrying FAD-related genetic mutations (mutations in presenilin 1: L85P, I143T, H163R, L166P, G206V,

Updated on: June 20,2024

Aβ43 generation in familial Alzheimer's disease: New insights into disease onset

by Doshisha UniversityIn this study, γ-secretase was extracted from wild type (WT) cells and cells carrying FAD-related genetic mutations (mutations in presenilin 1: L85P, I143T, H163R, L166P, G206V,

Updated on:June 20,2024

Immune cells identified as key players in brain health

byThe Mount Sinai HospitalThe Icahn Mount Sinai researchers nominated and validated transcription factors BHLHE40 and BHLHE41 that regulate clearance processes in immune cells, including brain i

Updated on: March 27,2024

Immune cells identified as key players in brain health

byThe Mount Sinai HospitalThe Icahn Mount Sinai researchers nominated and validated transcription factors BHLHE40 and BHLHE41 that regulate clearance processes in immune cells, including brain i

Updated on:March 27,2024

Docking peptides, slow to lock, open possible path to treat Alzheimer's

by Mike Williams,Rice UniversityUsing computational models and atomic force microscope experiments, researchers at the University of Houston and Rice University have identified a possible “Achil

Updated on: May 26,2024

Docking peptides, slow to lock, open possible path to treat Alzheimer's

by Mike Williams,Rice UniversityUsing computational models and atomic force microscope experiments, researchers at the University of Houston and Rice University have identified a possible “Achil

Updated on:May 26,2024

Are bigger brains better?

by Nancy Averett,Michigan State UniversityCredit: Michigan State UniversityWhen it comes to certain parts of the brain, bigger doesn't necessarily equate to better memory. According to a new

Updated on: May 18,2024

Are bigger brains better?

by Nancy Averett,Michigan State UniversityCredit: Michigan State UniversityWhen it comes to certain parts of the brain, bigger doesn't necessarily equate to better memory. According to a new

Updated on:May 18,2024

A potential agent for treating preeclampsia

by Max Delbrück Center for Molecular MedicineThis image helps researchers analyze, among other things, the spiral arteries in order to gain insights into fetal nutrition. Credit: Nadine Haase, MD

Updated on: May 11,2024

A potential agent for treating preeclampsia

by Max Delbrück Center for Molecular MedicineThis image helps researchers analyze, among other things, the spiral arteries in order to gain insights into fetal nutrition. Credit: Nadine Haase, MD

Updated on:May 11,2024