Cell-type-specific genetic risk contributes to distinct stages of Alzheimer's disease progression, finds study

by Brigham and Women's HospitalCell-type-specific Alzheimer’s disease polygenic risk scores (ADPRS).aA schematic of cell-type-specific PRS derivation.bAn UpSetR plot o

Updated on: February 24,2024

Cell-type-specific genetic risk contributes to distinct stages of Alzheimer's disease progression, finds study

by Brigham and Women's HospitalCell-type-specific Alzheimer’s disease polygenic risk scores (ADPRS).aA schematic of cell-type-specific PRS derivation.bAn UpSetR plot o

Updated on:February 24,2024

Tool to measure brain blood flow identifies tell-tale signs of dementia and Alzheimer's early

by COSTCredit: COSTA network of over 200 scientists, clinicians and industry partners developed a cost-effective diagnostic tool for measuring the tell-tale signs of dementia and Alzheimer's. The

Updated on: May 05,2024

Tool to measure brain blood flow identifies tell-tale signs of dementia and Alzheimer's early

by COSTCredit: COSTA network of over 200 scientists, clinicians and industry partners developed a cost-effective diagnostic tool for measuring the tell-tale signs of dementia and Alzheimer's. The

Updated on:May 05,2024

Concussions in young children: Symptoms still present three months later

byUniversity of MontrealCredit: Pixabay/CC0 Public DomainConcussions in children aged 6 and under continue to affect their health three months after the event. This is the finding of a study led

Updated on: March 28,2024

Concussions in young children: Symptoms still present three months later

byUniversity of MontrealCredit: Pixabay/CC0 Public DomainConcussions in children aged 6 and under continue to affect their health three months after the event. This is the finding of a study led

Updated on:March 28,2024

Unlocking the mystery of tau for treatment of neurodegenerative diseases

by Nagoya UniversityUnder normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functio

Updated on: July 01,2024

Unlocking the mystery of tau for treatment of neurodegenerative diseases

by Nagoya UniversityUnder normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functio

Updated on:July 01,2024

Individuals with high Alzheimer's risk may use attention to process, rather than suppress, distracting stimuli

by California Institute of TechnologyPractice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease. An example trial sequenc

Updated on: February 24,2024

Individuals with high Alzheimer's risk may use attention to process, rather than suppress, distracting stimuli

by California Institute of TechnologyPractice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease. An example trial sequenc

Updated on:February 24,2024

Overlooked brain organ plays key role in promoting brain repair after stroke, researchers discover

byUniversity of CincinnatiFluorescent image of a healthy choroid plexus, the main producer of cerebrospinal fluid in the brain. Credit: Agnes (Yu) LuoUniversity of Cincinnati researchers have pi

Updated on: July 08,2024

Overlooked brain organ plays key role in promoting brain repair after stroke, researchers discover

byUniversity of CincinnatiFluorescent image of a healthy choroid plexus, the main producer of cerebrospinal fluid in the brain. Credit: Agnes (Yu) LuoUniversity of Cincinnati researchers have pi

Updated on:July 08,2024

Hippocampal study unveils distinct protein machineries for calcium channel clustering and vesicle priming

by Ingrid Fadelli , Medical XpressMunc13-1 and CaV2.1 nanoclustering. a–c, Example STED images of sideview synapses (a), quantification of line profiles (b) and Pearson's colocalization coefficien

Updated on: September 23,2024

Hippocampal study unveils distinct protein machineries for calcium channel clustering and vesicle priming

by Ingrid Fadelli , Medical XpressMunc13-1 and CaV2.1 nanoclustering. a–c, Example STED images of sideview synapses (a), quantification of line profiles (b) and Pearson's colocalization coefficien

Updated on:September 23,2024

Negative wealth shock linked to accelerated cognitive decline

by Elana GotkineFor older adults, negative wealth shock is associated with accelerated cognitive decline and increased risks for dementia, according to a study published online Dec. 26 inJAMA Ne

Updated on: February 24,2024

Negative wealth shock linked to accelerated cognitive decline

by Elana GotkineFor older adults, negative wealth shock is associated with accelerated cognitive decline and increased risks for dementia, according to a study published online Dec. 26 inJAMA Ne

Updated on:February 24,2024

Does the risk of stroke from common risk factors change as people age?

by American Academy of NeurologyCredit: Unsplash/CC0 Public DomainHigh blood pressure and diabetes are known risk factors for stroke, but now a new study shows that the amount of risk may decreas

Updated on: February 05,2024

Does the risk of stroke from common risk factors change as people age?

by American Academy of NeurologyCredit: Unsplash/CC0 Public DomainHigh blood pressure and diabetes are known risk factors for stroke, but now a new study shows that the amount of risk may decreas

Updated on:February 05,2024

Scientists find a determining mechanism for synapse formation in the cerebellum

byMiguel Hernandez University of ElcheExpansion microscopy image with synaptic boutons (green) of climbing fibers on a Purkinje cell (blue) from the cerebellum of a mouse. Credit: CC BY IN-CSIC-

Updated on: July 11,2024

Scientists find a determining mechanism for synapse formation in the cerebellum

byMiguel Hernandez University of ElcheExpansion microscopy image with synaptic boutons (green) of climbing fibers on a Purkinje cell (blue) from the cerebellum of a mouse. Credit: CC BY IN-CSIC-

Updated on:July 11,2024

Synthetic peptide can inhibit toxicity, aggregation of protein in Alzheimer's disease

by University of WashingtonPET scan of a human brain with Alzheimer's disease. Credit: public domainAlzheimer's is a disease of aggregation. Neurons in the human brain make a protein call

Updated on: June 07,2024

Synthetic peptide can inhibit toxicity, aggregation of protein in Alzheimer's disease

by University of WashingtonPET scan of a human brain with Alzheimer's disease. Credit: public domainAlzheimer's is a disease of aggregation. Neurons in the human brain make a protein call

Updated on:June 07,2024

Sorting protein in neurons defends against neurodegenerative disease

by Temple UniversityDomenico Praticò, MD, Scott Richards North Star Foundation Chair for Alzheimer's Research, Professor in the Departments of Pharmacology and Microbiology, and Director of t

Updated on: May 26,2024

Sorting protein in neurons defends against neurodegenerative disease

by Temple UniversityDomenico Praticò, MD, Scott Richards North Star Foundation Chair for Alzheimer's Research, Professor in the Departments of Pharmacology and Microbiology, and Director of t

Updated on:May 26,2024