Cell-type-specific genetic risk contributes to distinct stages of Alzheimer's disease progression, finds study

by Brigham and Women's HospitalCell-type-specific Alzheimer’s disease polygenic risk scores (ADPRS).aA schematic of cell-type-specific PRS derivation.bAn UpSetR plot o

Updated on: February 24,2024

Cell-type-specific genetic risk contributes to distinct stages of Alzheimer's disease progression, finds study

by Brigham and Women's HospitalCell-type-specific Alzheimer’s disease polygenic risk scores (ADPRS).aA schematic of cell-type-specific PRS derivation.bAn UpSetR plot o

Updated on:February 24,2024

A wave theory for explaining neurochemical balance in the brain

byHebrew University of JerusalemAcetylcholine wave traveling from lateral (L) to medial (M) in the striatum Credit: Dr. Joshua Goldberg, Prof. Jeffery Wickens, Dr. Nicolas TristchIn a new study,

Updated on: January 12,2024

A wave theory for explaining neurochemical balance in the brain

byHebrew University of JerusalemAcetylcholine wave traveling from lateral (L) to medial (M) in the striatum Credit: Dr. Joshua Goldberg, Prof. Jeffery Wickens, Dr. Nicolas TristchIn a new study,

Updated on:January 12,2024

Down syndrome carries raised risk of dementia by 55

(HealthDay)—Most people with Down syndrome have dementia by age 55, a new study shows.People with Down syndrome are born with an extra copy of chromosome 21, which often results in developmental disab

Updated on: June 07,2024

Down syndrome carries raised risk of dementia by 55

(HealthDay)—Most people with Down syndrome have dementia by age 55, a new study shows.People with Down syndrome are born with an extra copy of chromosome 21, which often results in developmental disab

Updated on:June 07,2024

Clinical trial suggests ALS drug effective for treating spinal cord injuries

by Laurie Fickman,University of HoustonRiluzole trough and peak concentrations from Phase I and Phase II/III trials presented in waterfall plots. Credit:Journal of Neurotrauma(2023).

Updated on: January 11,2024

Clinical trial suggests ALS drug effective for treating spinal cord injuries

by Laurie Fickman,University of HoustonRiluzole trough and peak concentrations from Phase I and Phase II/III trials presented in waterfall plots. Credit:Journal of Neurotrauma(2023).

Updated on:January 11,2024

5 ways to lower your chances of getting Alzheimer's

by University of Southern CaliforniaCredit: University of Southern CaliforniaRetain a sharp, healthy brain and reduce your risk of Alzheimer's disease by following five simple rules. Some of

Updated on: June 24,2024

5 ways to lower your chances of getting Alzheimer's

by University of Southern CaliforniaCredit: University of Southern CaliforniaRetain a sharp, healthy brain and reduce your risk of Alzheimer's disease by following five simple rules. Some of

Updated on:June 24,2024

Silencing a faulty gene may uncover clues to rare forms of ALS

by National Institutes of HealthCredit: Pixabay/CC0 Public DomainUsing an experimental drug, researchers have been able to suppress a mutated amyotrophic lateral sclerosis (ALS) gene. Studies in

Updated on: February 05,2024

Silencing a faulty gene may uncover clues to rare forms of ALS

by National Institutes of HealthCredit: Pixabay/CC0 Public DomainUsing an experimental drug, researchers have been able to suppress a mutated amyotrophic lateral sclerosis (ALS) gene. Studies in

Updated on:February 05,2024

Unlocking the mystery of tau for treatment of neurodegenerative diseases

by Nagoya UniversityUnder normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functio

Updated on: July 01,2024

Unlocking the mystery of tau for treatment of neurodegenerative diseases

by Nagoya UniversityUnder normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functio

Updated on:July 01,2024

How a mutation in microglia elevates Alzheimer's risk

byMassachusetts Institute of TechnologyBright green staining highlights human microglia implanted in the hippocampus region of the brain of a mouse. Credit: Jay Penney/MIT Picower InstituteA rar

Updated on: January 10,2024

How a mutation in microglia elevates Alzheimer's risk

byMassachusetts Institute of TechnologyBright green staining highlights human microglia implanted in the hippocampus region of the brain of a mouse. Credit: Jay Penney/MIT Picower InstituteA rar

Updated on:January 10,2024

For Alzheimer's patients, a controversial drug brings hope

by Hannah Critchfield and Kirby WilsonCredit: Pixabay/CC0 Public DomainAt 53, Michele Hall was at the height of her legal career. She'd just sent her three kids to college. She had decades ahead w

Updated on: May 26,2024

For Alzheimer's patients, a controversial drug brings hope

by Hannah Critchfield and Kirby WilsonCredit: Pixabay/CC0 Public DomainAt 53, Michele Hall was at the height of her legal career. She'd just sent her three kids to college. She had decades ahead w

Updated on:May 26,2024

Alzheimer's disease could be treated with gene therapy, animal study suggests

by Imperial College LondonBrain cells from a mouse cortex that didn't receive the gene therapy. The amyloid plaques are shown in green, and the glial cells, which surround the plaques, are sh

Updated on: May 22,2024

Alzheimer's disease could be treated with gene therapy, animal study suggests

by Imperial College LondonBrain cells from a mouse cortex that didn't receive the gene therapy. The amyloid plaques are shown in green, and the glial cells, which surround the plaques, are sh

Updated on:May 22,2024

Individuals with high Alzheimer's risk may use attention to process, rather than suppress, distracting stimuli

by California Institute of TechnologyPractice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease. An example trial sequenc

Updated on: February 24,2024

Individuals with high Alzheimer's risk may use attention to process, rather than suppress, distracting stimuli

by California Institute of TechnologyPractice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease. An example trial sequenc

Updated on:February 24,2024

Physical activity level inversely linked to Parkinson's disease in women

by Elana GotkineIn women, a higher physical activity (PA) level is associated with a lower incidence of Parkinson's disease (PD), according to a study published online May 17 inNeurology.Ber

Updated on: May 16,2024

Physical activity level inversely linked to Parkinson's disease in women

by Elana GotkineIn women, a higher physical activity (PA) level is associated with a lower incidence of Parkinson's disease (PD), according to a study published online May 17 inNeurology.Ber

Updated on:May 16,2024