Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on: January 11,2024 10

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on:January 11,2024 10

Diagnosis of Alzheimer's disease: Llama antibodies detect cerebral lesions

by Institut PasteurThe specific VHH antibody for plaques, labeled with a green fluorochrome, is injected into mice. The VHH travels along the blood vessels before marking the plaques in the brain. Pho

Updated on: April 08,2024 13

Diagnosis of Alzheimer's disease: Llama antibodies detect cerebral lesions

by Institut PasteurThe specific VHH antibody for plaques, labeled with a green fluorochrome, is injected into mice. The VHH travels along the blood vessels before marking the plaques in the brain. Pho

Updated on:April 08,2024 13

Restoring 'chaperone' protein may prevent plaque build-up in Alzheimer's

by Perelman School of Medicine at the University of PennsylvaniaDAXX (red color at top) prevents the aggregation of mutant p53 protein associated with cancers (dark green color at bottom) in cell

Updated on: June 11,2024 7

Restoring 'chaperone' protein may prevent plaque build-up in Alzheimer's

by Perelman School of Medicine at the University of PennsylvaniaDAXX (red color at top) prevents the aggregation of mutant p53 protein associated with cancers (dark green color at bottom) in cell

Updated on:June 11,2024 7

Early diagnosis of Alzheimer's: Ultra-long protein fibrils give clues on dementia risk

by Swiss Federal Laboratories for Materials Science and TechnologyAtomic force microscopy: Peter Nirmalraj investigates Alzheimer's disease at the nanometer scale. Credit: EmpaThe early detec

Updated on: April 18,2024 19

Early diagnosis of Alzheimer's: Ultra-long protein fibrils give clues on dementia risk

by Swiss Federal Laboratories for Materials Science and TechnologyAtomic force microscopy: Peter Nirmalraj investigates Alzheimer's disease at the nanometer scale. Credit: EmpaThe early detec

Updated on:April 18,2024 19

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on: March 25,2024 18

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on:March 25,2024 18

Improving quality of life and sleep in people with memory problems without using drugs

by University of Pennsylvania School of NursingCredit: Pixabay/CC0 Public DomainA study from the University of Pennsylvania School of Nursing (Penn Nursing), recentlypublishedin

Updated on: March 05,2024 17

Improving quality of life and sleep in people with memory problems without using drugs

by University of Pennsylvania School of NursingCredit: Pixabay/CC0 Public DomainA study from the University of Pennsylvania School of Nursing (Penn Nursing), recentlypublishedin

Updated on:March 05,2024 17

Too few seniors are getting their memory tested

by Serena Gordon, Healthday Reporter(HealthDay)—Most seniors expect their doctor to recommend testing of thinking and memory when it's needed.But a new survey discovered that is rarely the case: O

Updated on: June 07,2024 6

Too few seniors are getting their memory tested

by Serena Gordon, Healthday Reporter(HealthDay)—Most seniors expect their doctor to recommend testing of thinking and memory when it's needed.But a new survey discovered that is rarely the case: O

Updated on:June 07,2024 6

Alzheimer's treatment holds promise for primary progressive aphasia patients

by Northwestern UniversityCredit: CC0 Public DomainNorthwestern Medicine scientists have discovered that an existing therapy frequently used to treat Alzheimer's disease might also work on pa

Updated on: April 08,2024 10

Alzheimer's treatment holds promise for primary progressive aphasia patients

by Northwestern UniversityCredit: CC0 Public DomainNorthwestern Medicine scientists have discovered that an existing therapy frequently used to treat Alzheimer's disease might also work on pa

Updated on:April 08,2024 10

Researchers find connections between neuroinflammation and Alzheimer's disease

by Brigham and Women's HospitalINPP5D expression in the human brain is restricted to microglia in the human brain. Credit:Nature Communications(2023). DOI: 10.1038/s41467-023-4281

Updated on: June 19,2024 3

Researchers find connections between neuroinflammation and Alzheimer's disease

by Brigham and Women's HospitalINPP5D expression in the human brain is restricted to microglia in the human brain. Credit:Nature Communications(2023). DOI: 10.1038/s41467-023-4281

Updated on:June 19,2024 3

Docking peptides, slow to lock, open possible path to treat Alzheimer's

by Mike Williams,Rice UniversityUsing computational models and atomic force microscope experiments, researchers at the University of Houston and Rice University have identified a possible “Achil

Updated on: May 26,2024 4

Docking peptides, slow to lock, open possible path to treat Alzheimer's

by Mike Williams,Rice UniversityUsing computational models and atomic force microscope experiments, researchers at the University of Houston and Rice University have identified a possible “Achil

Updated on:May 26,2024 4

Experiments on mice reveal the parts of the brain involved in motion sickness

by Bob Yirka , Medical XpressIdentification of glutamatergic neuronal subpopulations in the VN. (A)Slc17a6Cremice were bilaterally injected in the VN with a viral vector expressing the Rib

Updated on: January 11,2024 10

Experiments on mice reveal the parts of the brain involved in motion sickness

by Bob Yirka , Medical XpressIdentification of glutamatergic neuronal subpopulations in the VN. (A)Slc17a6Cremice were bilaterally injected in the VN with a viral vector expressing the Rib

Updated on:January 11,2024 10

AI helping bring vital stroke care 'virtually to the patient's bedside'

JANUARY 19, 2024by Audrey Kirby,University of KentuckyJustin Fraser, M.D., and Muhammed Fawad Ishfaq, M.D., are able to quickly review patient scans through their phones. Credit: Lily Wilder/Uni

Updated on: March 13,2024 8

AI helping bring vital stroke care 'virtually to the patient's bedside'

JANUARY 19, 2024by Audrey Kirby,University of KentuckyJustin Fraser, M.D., and Muhammed Fawad Ishfaq, M.D., are able to quickly review patient scans through their phones. Credit: Lily Wilder/Uni

Updated on:March 13,2024 8