Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on: July 25,2024

Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on:July 25,2024

Study reveals insights into link between genetic mutation and Parkinson's

by Bill Hathaway,Yale UniversityLRRK2 inhibits lysosomal protease activity in human iPSC-derived macrophages. (A) Airyscan live cell confocal micrographs showing lysosome labeling in human iPSC-

Updated on: April 26,2024

Study reveals insights into link between genetic mutation and Parkinson's

by Bill Hathaway,Yale UniversityLRRK2 inhibits lysosomal protease activity in human iPSC-derived macrophages. (A) Airyscan live cell confocal micrographs showing lysosome labeling in human iPSC-

Updated on:April 26,2024

Is risk of Alzheimer's linked to specific sleep patterns?

by American Academy of NeurologyPET scan of a human brain with Alzheimer's disease. Credit: public domainDisturbed sleep patterns do not cause Alzheimer's disease but people who are at hi

Updated on: June 07,2024

Is risk of Alzheimer's linked to specific sleep patterns?

by American Academy of NeurologyPET scan of a human brain with Alzheimer's disease. Credit: public domainDisturbed sleep patterns do not cause Alzheimer's disease but people who are at hi

Updated on:June 07,2024

Public health initiatives can support caregivers of people with Alzheimer's and related dementia

by University of MinnesotaConceptual model: Intersection of social determinants of health and dementia caregiving. Credit:Alzheimer's & Dementia(2023). DOI: 10.1002/alz.13437U

Updated on: March 02,2024

Public health initiatives can support caregivers of people with Alzheimer's and related dementia

by University of MinnesotaConceptual model: Intersection of social determinants of health and dementia caregiving. Credit:Alzheimer's & Dementia(2023). DOI: 10.1002/alz.13437U

Updated on:March 02,2024

More parents are delaying their kids' vaccines, and it's alarming pediatricians

by Jenny Gold, Los Angeles TimesCredit: Unsplash/CC0 Public DomainAs measles cases pop up across the country this winter—including several in California—one group of children is stirring deep concerns

Updated on: March 19,2024

More parents are delaying their kids' vaccines, and it's alarming pediatricians

by Jenny Gold, Los Angeles TimesCredit: Unsplash/CC0 Public DomainAs measles cases pop up across the country this winter—including several in California—one group of children is stirring deep concerns

Updated on:March 19,2024

Immune cells of the brain are not all the same: New research could open novel therapeutic pathways

by University of HelsinkiMicroglia (in red) surround an ARG1+microglia cell (in yellow) that expresses the enzyme ARG1. Credit: Vassilis StratouliasA recent study published inNature Neurosc

Updated on: February 21,2024

Immune cells of the brain are not all the same: New research could open novel therapeutic pathways

by University of HelsinkiMicroglia (in red) surround an ARG1+microglia cell (in yellow) that expresses the enzyme ARG1. Credit: Vassilis StratouliasA recent study published inNature Neurosc

Updated on:February 21,2024

'Viral relicts' in the genome could fuel neurodegeneration

by Marcus Neitzert, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)Different HERV glycoproteins increase intercellular protein aggregate spreading.aExperimental workflow.

Updated on: June 18,2024

'Viral relicts' in the genome could fuel neurodegeneration

by Marcus Neitzert, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)Different HERV glycoproteins increase intercellular protein aggregate spreading.aExperimental workflow.

Updated on:June 18,2024

Insulin resistance in shift workers not affected by melatonin treatment, finds study

by University of SurreyTime course of serum glucose and insulin concentrations during oral glucose tolerance testing in night shift workers at baseline, after 12 weeks, and after 24 weeks as comp

Updated on: March 05,2024

Insulin resistance in shift workers not affected by melatonin treatment, finds study

by University of SurreyTime course of serum glucose and insulin concentrations during oral glucose tolerance testing in night shift workers at baseline, after 12 weeks, and after 24 weeks as comp

Updated on:March 05,2024

Optimizing chronic subdural hematoma treatment

by Cactus CommunicationsThe MRCSDH is the first nationwide study in mainland China to assess the safety and efficacy of different treatment approaches for CSDH. Its findings can help the medical commu

Updated on: April 06,2024

Optimizing chronic subdural hematoma treatment

by Cactus CommunicationsThe MRCSDH is the first nationwide study in mainland China to assess the safety and efficacy of different treatment approaches for CSDH. Its findings can help the medical commu

Updated on:April 06,2024

Innovative method identifies rare brain cell types for the first time

by Katherine Fenz,Rockefeller UniversityEasySci enables high-throughput and low-cost single-cell transcriptome and chromatin accessibility profiling across the entire mammalian brain. Credit:&nb

Updated on: February 05,2024

Innovative method identifies rare brain cell types for the first time

by Katherine Fenz,Rockefeller UniversityEasySci enables high-throughput and low-cost single-cell transcriptome and chromatin accessibility profiling across the entire mammalian brain. Credit:&nb

Updated on:February 05,2024

Early-life exposure to manganese may be beneficial to adolescent cognition

by Jillian McKoy,Boston UniversityAdjusted beta (β) estimates and 95% CIs from multivariable linear regression models assessing associations between prenatal, postnatal, and childhood tooth Mn l

Updated on: January 10,2024

Early-life exposure to manganese may be beneficial to adolescent cognition

by Jillian McKoy,Boston UniversityAdjusted beta (β) estimates and 95% CIs from multivariable linear regression models assessing associations between prenatal, postnatal, and childhood tooth Mn l

Updated on:January 10,2024

Prospects continue to improve for people with MS, but disease management in older adults presents challenges

by Ellen Goldbaum,University at BuffaloCredit: Anna Shvets from PexelsThe past five years have seen significant advancements in diagnosing and treating multiple sclerosis (MS), but challenges re

Updated on: January 10,2024

Prospects continue to improve for people with MS, but disease management in older adults presents challenges

by Ellen Goldbaum,University at BuffaloCredit: Anna Shvets from PexelsThe past five years have seen significant advancements in diagnosing and treating multiple sclerosis (MS), but challenges re

Updated on:January 10,2024