Study: Key mechanisms of action differences in immune checkpoint inhibitor combination therapies for advanced melanoma

byH. Lee Moffitt Cancer Center & Research InstituteProposed mechanism of the two ICI combinations. Graphic created with Biorender (biorender.com). ICI, immune checkpoint inhibitor. Credit:&n

Updated on: January 25,2024

Study: Key mechanisms of action differences in immune checkpoint inhibitor combination therapies for advanced melanoma

byH. Lee Moffitt Cancer Center & Research InstituteProposed mechanism of the two ICI combinations. Graphic created with Biorender (biorender.com). ICI, immune checkpoint inhibitor. Credit:&n

Updated on:January 25,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on: April 09,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on:April 09,2024

Adjuvant therapy for hepatocellular carcinoma after curative treatment: Several unanswered questions

by Xia & He PublishingICI, immune checkpoint inhibitor. Credit: Jian-Hong Zhong, Liang Ma, Le Li, Zhen-Zhen LiHepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and

Updated on: July 17,2024

Adjuvant therapy for hepatocellular carcinoma after curative treatment: Several unanswered questions

by Xia & He PublishingICI, immune checkpoint inhibitor. Credit: Jian-Hong Zhong, Liang Ma, Le Li, Zhen-Zhen LiHepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and

Updated on:July 17,2024

'Magic bullet' takes aim at pancreatic cancer

by University of South AustraliaAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainEvery day, more than 1200 people worldwide are told they

Updated on: March 14,2024

'Magic bullet' takes aim at pancreatic cancer

by University of South AustraliaAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainEvery day, more than 1200 people worldwide are told they

Updated on:March 14,2024

Tackling resistance to HIF2 drugs with an RNA-based therapy

byUT Southwestern Medical CenterDownregulation of HIF2α by ARO-HIF2 in patient tumor biopsies. Credit: Dr. Payal KapurExpected to be diagnosed in 2% of men and 1% of women in the U.S., kidney ca

Updated on: December 28,2023

Tackling resistance to HIF2 drugs with an RNA-based therapy

byUT Southwestern Medical CenterDownregulation of HIF2α by ARO-HIF2 in patient tumor biopsies. Credit: Dr. Payal KapurExpected to be diagnosed in 2% of men and 1% of women in the U.S., kidney ca

Updated on:December 28,2023

High-resolution brain tumor mapping reveals possible reason why some patients don't respond to new drug

byWeizmann Institute of ScienceGraphical abstract. Credit:Cell(2024). DOI: 10.1016/j.cell.2024.03.029The cells that make up cancerous brain tumors are extremely varied and sometimes

Updated on: September 10,2024

High-resolution brain tumor mapping reveals possible reason why some patients don't respond to new drug

byWeizmann Institute of ScienceGraphical abstract. Credit:Cell(2024). DOI: 10.1016/j.cell.2024.03.029The cells that make up cancerous brain tumors are extremely varied and sometimes

Updated on:September 10,2024

Novel AI method identifies locations, interactions among genes in and around tumors

byJohns Hopkins University School of MedicineImage of a breast cancer tissue sample overlaid with visual representations of spatially interacting patterns of tumor and immune activity obtained t

Updated on: January 12,2024

Novel AI method identifies locations, interactions among genes in and around tumors

byJohns Hopkins University School of MedicineImage of a breast cancer tissue sample overlaid with visual representations of spatially interacting patterns of tumor and immune activity obtained t

Updated on:January 12,2024

Wide variation in bowel cancer rates after colonoscopies in England

by British Medical JournalBowel cancer survivor John Barnes. Credit: University of LeedsSubstantial variation exists between colonoscopy providers in rates of bowel cancer up to three years after

Updated on: May 11,2024

Wide variation in bowel cancer rates after colonoscopies in England

by British Medical JournalBowel cancer survivor John Barnes. Credit: University of LeedsSubstantial variation exists between colonoscopy providers in rates of bowel cancer up to three years after

Updated on:May 11,2024

Pulsed electromagnetic field application technique for preventing bone loss due to radiotherapy

by Bob Yirka , Medical XpressPEMF ameliorates focal radiation–induced bone loss by modulating osteoblasts. (A) Schematic representation of focal radiation and PEMF administration. (B) Representative m

Updated on: December 28,2023

Pulsed electromagnetic field application technique for preventing bone loss due to radiotherapy

by Bob Yirka , Medical XpressPEMF ameliorates focal radiation–induced bone loss by modulating osteoblasts. (A) Schematic representation of focal radiation and PEMF administration. (B) Representative m

Updated on:December 28,2023

New study identifies ganoderic acid DM as potential treatment for breast cancer

byChinese Academy of SciencesProtein-protein interaction network of the 53 potential targets for treating breast cancer. Credit: Mohammed Sharif SwallahBreast cancer is one of the most common ca

Updated on: October 22,2024

New study identifies ganoderic acid DM as potential treatment for breast cancer

byChinese Academy of SciencesProtein-protein interaction network of the 53 potential targets for treating breast cancer. Credit: Mohammed Sharif SwallahBreast cancer is one of the most common ca

Updated on:October 22,2024

Using cryo-shocked tumor cells to fight lung cancer

by Bob Yirka , Medical XpressSchedule of LNT cells delivery of CRISPR-Cas9 nanoparticles for KRAS-mutant NSCLC treatment. Credit:Science Advances(2024). DOI: 10.1126/sciadv.adk8264A team o

Updated on: April 06,2024

Using cryo-shocked tumor cells to fight lung cancer

by Bob Yirka , Medical XpressSchedule of LNT cells delivery of CRISPR-Cas9 nanoparticles for KRAS-mutant NSCLC treatment. Credit:Science Advances(2024). DOI: 10.1126/sciadv.adk8264A team o

Updated on:April 06,2024

Breast cancer spread uncovered by new molecular microscopy

byWellcome Trust Sanger InstituteConverting BaSISS spatial signals into maps of clones.a, Bar plots of cancer cell fractions (CCFs) derived from bulk WGS of the P1 samples.b, P

Updated on: January 11,2024

Breast cancer spread uncovered by new molecular microscopy

byWellcome Trust Sanger InstituteConverting BaSISS spatial signals into maps of clones.a, Bar plots of cancer cell fractions (CCFs) derived from bulk WGS of the P1 samples.b, P

Updated on:January 11,2024