Study validates clinical utility of pan-tumor predictive biomarker for checkpoint inhibitor immunotherapy benefit

by Strata OncologyDevelopment of an integrative immunotherapy response score (IRS) model to stratify PD-(L)1 therapy benefit in patients with advanced solid tumors.aReal-world treatment an

Updated on: February 03,2024

Study validates clinical utility of pan-tumor predictive biomarker for checkpoint inhibitor immunotherapy benefit

by Strata OncologyDevelopment of an integrative immunotherapy response score (IRS) model to stratify PD-(L)1 therapy benefit in patients with advanced solid tumors.aReal-world treatment an

Updated on:February 03,2024

New method eradicates deadly brain tumors by 'starving' them of energy source

byTel Aviv UniversityDr. Lior Mayo and students. Credit: Tel Aviv UniversityA groundbreaking study at Tel Aviv University effectively eradicated glioblastoma, a highly lethal type of brain cance

Updated on: January 13,2024

New method eradicates deadly brain tumors by 'starving' them of energy source

byTel Aviv UniversityDr. Lior Mayo and students. Credit: Tel Aviv UniversityA groundbreaking study at Tel Aviv University effectively eradicated glioblastoma, a highly lethal type of brain cance

Updated on:January 13,2024

Researchers identify cell signaling pathways controlling melanoma cell metastasis to the brain

by H. Lee Moffitt Cancer Center & Research InstituteHDAC8 increases the establishment of melanoma brain metastases.a–cHDAC8 and EV expressing WM164 cells were introduced into NOD.

Updated on: June 22,2024

Researchers identify cell signaling pathways controlling melanoma cell metastasis to the brain

by H. Lee Moffitt Cancer Center & Research InstituteHDAC8 increases the establishment of melanoma brain metastases.a–cHDAC8 and EV expressing WM164 cells were introduced into NOD.

Updated on:June 22,2024

Researchers identify mechanism of resistance to BRAF inhibitors in melanoma

by H. Lee Moffitt Cancer Center & Research InstituteMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0Melanoma i

Updated on: June 08,2024

Researchers identify mechanism of resistance to BRAF inhibitors in melanoma

by H. Lee Moffitt Cancer Center & Research InstituteMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0Melanoma i

Updated on:June 08,2024

Ancient viruses could help kill cancers

by The Francis Crick InstituteHeatmap showing expression of melanoma-specific transcripts across a range of cancer types. The three columns with high expression are from melanoma samples. Credit:

Updated on: March 30,2024

Ancient viruses could help kill cancers

by The Francis Crick InstituteHeatmap showing expression of melanoma-specific transcripts across a range of cancer types. The three columns with high expression are from melanoma samples. Credit:

Updated on:March 30,2024

Synthetic molecule proves able to mitigate heart failure in translational study

by Maria Fernanda Ziegler,FAPESPThe vicious cycle of heart failure (HF). (i) Impaired aldehyde metabolism by aldehyde dehydrogenase 2 (ALDH2); (ii) accumulation of 4-hydroxynonenal (4-HNE), a re

Updated on: April 01,2024

Synthetic molecule proves able to mitigate heart failure in translational study

by Maria Fernanda Ziegler,FAPESPThe vicious cycle of heart failure (HF). (i) Impaired aldehyde metabolism by aldehyde dehydrogenase 2 (ALDH2); (ii) accumulation of 4-hydroxynonenal (4-HNE), a re

Updated on:April 01,2024

A new strategy 'raises the volume' of gut-body communication

by Ana María Rodríguez, Ph.d.,Baylor College of MedicineCredit: CC0 Public DomainThroughout the gastrointestinal tract there are specialized hormone-producing cells called enteroendocrine cells

Updated on: May 23,2024

A new strategy 'raises the volume' of gut-body communication

by Ana María Rodríguez, Ph.d.,Baylor College of MedicineCredit: CC0 Public DomainThroughout the gastrointestinal tract there are specialized hormone-producing cells called enteroendocrine cells

Updated on:May 23,2024

Previously unidentified proteins suggest new way to diagnose ovarian cancer

by Nagoya UniversityExtracellular vesicles (EVs) are vesicles with lipid-bilayer structures (shown in center), and three proteins expressed on small EVs called exosomes (shown in red, green, blue

Updated on: February 23,2024

Previously unidentified proteins suggest new way to diagnose ovarian cancer

by Nagoya UniversityExtracellular vesicles (EVs) are vesicles with lipid-bilayer structures (shown in center), and three proteins expressed on small EVs called exosomes (shown in red, green, blue

Updated on:February 23,2024

The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia

by Justin Jackson , Medical XpressCohesin regulates alternative splicing. (A) Flowchart showing the experimental protocol, as detailed in Materials and Methods. (B) Schematic showing five different cl

Updated on: January 02,2024

The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia

by Justin Jackson , Medical XpressCohesin regulates alternative splicing. (A) Flowchart showing the experimental protocol, as detailed in Materials and Methods. (B) Schematic showing five different cl

Updated on:January 02,2024

Revealing characteristics of circulating cell-free RNA in the blood of liver cancer patients

byScience China PressMOF materials efficiently enrich circulating nucleic acids (cfDNA and cfRNA) in blood through a simple operational process, enabling various downstream nucleic acid detectio

Updated on: March 30,2024

Revealing characteristics of circulating cell-free RNA in the blood of liver cancer patients

byScience China PressMOF materials efficiently enrich circulating nucleic acids (cfDNA and cfRNA) in blood through a simple operational process, enabling various downstream nucleic acid detectio

Updated on:March 30,2024

Study discovers tumor monocyte content predicts immunochemotherapy outcomes for esophageal cancer

by Ludwig Institute for Cancer ResearchGraphical Abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.06.006A Ludwig Cancer Research study has discovered that the presence of

Updated on: February 01,2024

Study discovers tumor monocyte content predicts immunochemotherapy outcomes for esophageal cancer

by Ludwig Institute for Cancer ResearchGraphical Abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.06.006A Ludwig Cancer Research study has discovered that the presence of

Updated on:February 01,2024

BMI's relation to cancer therapy mortality risks not so straightforward, study finds

byOsaka Metropolitan UniversityFor non-small cell lung cancer treatment, immunotherapy seems to pose less risk for persons under a certain BMI, while conventional chemotherapy appears optimal fo

Updated on: September 27,2024

BMI's relation to cancer therapy mortality risks not so straightforward, study finds

byOsaka Metropolitan UniversityFor non-small cell lung cancer treatment, immunotherapy seems to pose less risk for persons under a certain BMI, while conventional chemotherapy appears optimal fo

Updated on:September 27,2024