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Oncology
Prevention and treatment of tumors, and caring for cancer patients.
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Adcetris FDA approval expanded to include later-stage Hodgkin's

Adcetris FDA approval expanded to include later-stage Hodgkin's

(HealthDay)—U.S. Food and Drug Administration approval of Adcetris (brentuximab vedotin) has been expanded to include adults with untreated stage III or IV classical Hodgkin's lymphoma, the agency

Adcetris FDA approval expanded to include later-stage Hodgkin's

(HealthDay)—U.S. Food and Drug Administration approval of Adcetris (brentuximab vedotin) has been expanded to include adults with untreated stage III or IV classical Hodgkin's lymphoma, the agency
Novel therapeutic strategy against melanoma: Combined targeting of hedgehog signaling and BRD4

Novel therapeutic strategy against melanoma: Combined targeting of hedgehog signaling and BRD4

by Impact Journals LLCCombined targeting of SMO and BRD4 as a potential therapeutic strategy against melanoma. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28441A new editorial paper

Novel therapeutic strategy against melanoma: Combined targeting of hedgehog signaling and BRD4

by Impact Journals LLCCombined targeting of SMO and BRD4 as a potential therapeutic strategy against melanoma. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28441A new editorial paper
Enhanced anticancer compound may allow precise activation and tracking of treatment

Enhanced anticancer compound may allow precise activation and tracking of treatment

by The Wistar InstituteCredit: The Wistar InstituteResearchers at The Wistar Institute and the University of South Florida have advanced a novel compound that specifically targets the endoplasmic

Enhanced anticancer compound may allow precise activation and tracking of treatment

by The Wistar InstituteCredit: The Wistar InstituteResearchers at The Wistar Institute and the University of South Florida have advanced a novel compound that specifically targets the endoplasmic
Post-Transplant Cyclophosphamide-Based GVHD Prophylaxis Bests Standard Regimen in Phase III Study

Post-Transplant Cyclophosphamide-Based GVHD Prophylaxis Bests Standard Regimen in Phase III Study

October 2023Katie RobinsonPatients undergoing a human leukocyte antigen (HLA)-matched allogeneic hematopoietic cell transplantation (alloHCT) with reduced-intensity conditioning who received a prophyl

Post-Transplant Cyclophosphamide-Based GVHD Prophylaxis Bests Standard Regimen in Phase III Study

October 2023Katie RobinsonPatients undergoing a human leukocyte antigen (HLA)-matched allogeneic hematopoietic cell transplantation (alloHCT) with reduced-intensity conditioning who received a prophyl
Specialized immune cells carry potential for new cancer immunotherapies

Specialized immune cells carry potential for new cancer immunotherapies

byLeiden UniversityTumor-infiltrating Vδ1 and Vδ3 T cell subsets display hallmarks of cytotoxic activity in MMR-d colon cancers. a, UMAP embedding showing the clustering of γδ T cells (n = 4,442

Specialized immune cells carry potential for new cancer immunotherapies

byLeiden UniversityTumor-infiltrating Vδ1 and Vδ3 T cell subsets display hallmarks of cytotoxic activity in MMR-d colon cancers. a, UMAP embedding showing the clustering of γδ T cells (n = 4,442
Study could explain link between high-cholesterol diet and colon cancer

Study could explain link between high-cholesterol diet and colon cancer

by University of California, Los AngelesA pale-blue stain shows stem cells multiplying in a mouse's intestine. Credit: Tontonoz lab/UCLANew UCLA research could help explain the link between a

Study could explain link between high-cholesterol diet and colon cancer

by University of California, Los AngelesA pale-blue stain shows stem cells multiplying in a mouse's intestine. Credit: Tontonoz lab/UCLANew UCLA research could help explain the link between a
HPV immunization program cuts pre-cancer rates by more than half

HPV immunization program cuts pre-cancer rates by more than half

by University of British ColumbiaGardasil vaccine and box. Image: WikipediaA school-based human papillomavirus (HPV) immunization program in British Columbia, Canada, is dramatically reducing rat

HPV immunization program cuts pre-cancer rates by more than half

by University of British ColumbiaGardasil vaccine and box. Image: WikipediaA school-based human papillomavirus (HPV) immunization program in British Columbia, Canada, is dramatically reducing rat
Researchers identify potential biomarker to distinguish two aggressive types of brain tumors in children

Researchers identify potential biomarker to distinguish two aggressive types of brain tumors in children

by Johns Hopkins University School of MedicineSMYD3 overexpression activates the EGFR pathway in CHLA01 cells. (A) Localization of endogenous SMYD3. Representative 60x Z-stack confocal images sho

Researchers identify potential biomarker to distinguish two aggressive types of brain tumors in children

by Johns Hopkins University School of MedicineSMYD3 overexpression activates the EGFR pathway in CHLA01 cells. (A) Localization of endogenous SMYD3. Representative 60x Z-stack confocal images sho
Overweight before age 40 increases cancer risk

Overweight before age 40 increases cancer risk

by Kim E. Andreassen,University of BergenObesity is a risk factor for many types of cancer. Credit: Colourbox.In an international study, lead by the University of Bergen, the researchers wanted

Overweight before age 40 increases cancer risk

by Kim E. Andreassen,University of BergenObesity is a risk factor for many types of cancer. Credit: Colourbox.In an international study, lead by the University of Bergen, the researchers wanted
Cellular origins of pediatric brain tumors identified

Cellular origins of pediatric brain tumors identified

by McGill UniversityCredit: CC0 Public DomainA research team led by Dr. Claudia Kleinman, an investigator at the Lady Davis Institute at the Jewish General Hospital, together with Dr. Nada Jabado

Cellular origins of pediatric brain tumors identified

by McGill UniversityCredit: CC0 Public DomainA research team led by Dr. Claudia Kleinman, an investigator at the Lady Davis Institute at the Jewish General Hospital, together with Dr. Nada Jabado
Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

by Baylor College of MedicineDr. Xiang 'Shawn' Zhang, the corresponding author of this work. Credit: Baylor College of MedicineIn recent years it has been increasingly appreciated that im

Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

by Baylor College of MedicineDr. Xiang 'Shawn' Zhang, the corresponding author of this work. Credit: Baylor College of MedicineIn recent years it has been increasingly appreciated that im
Neurofeedback shows promise for addressing 'chemo brain' in pilot study

Neurofeedback shows promise for addressing 'chemo brain' in pilot study

by University of California, Los AngelesCredit: CC0 Public DomainRestoring normal functioning in the brains of cancer patients through neurofeedback could potentially alleviate the mental foggine

Neurofeedback shows promise for addressing 'chemo brain' in pilot study

by University of California, Los AngelesCredit: CC0 Public DomainRestoring normal functioning in the brains of cancer patients through neurofeedback could potentially alleviate the mental foggine