Deep proteomic profiling reveals possible therapeutic targets for medulloblastoma

byTranslational Genomics Research InstituteSample overview and subgroup classification. (A) Common molecular alterations and subgroup classifications of 20 MB PDX models. (B) Partial least squar

Updated on: January 04,2024

Deep proteomic profiling reveals possible therapeutic targets for medulloblastoma

byTranslational Genomics Research InstituteSample overview and subgroup classification. (A) Common molecular alterations and subgroup classifications of 20 MB PDX models. (B) Partial least squar

Updated on:January 04,2024

Study offers way to increase immune checkpoint inhibitor effectiveness in patients with MTAP-deleted cancers

by Dana-Farber Cancer InstituteGraphical abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.09.005Loss of the "housekeeping" gene methylthioadenosine phosphorylas

Updated on: February 01,2024

Study offers way to increase immune checkpoint inhibitor effectiveness in patients with MTAP-deleted cancers

by Dana-Farber Cancer InstituteGraphical abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.09.005Loss of the "housekeeping" gene methylthioadenosine phosphorylas

Updated on:February 01,2024

Researchers develop novel gold-nanocluster-based tumor radiodynamic therapy

by Zhang Nannan,Chinese Academy of SciencesGold-nanocluster-based radiodynamic therapy. Credit: IGDBRadiotherapy (RT) is a primary method of tumor treatment. However, in clinical practice, radio

Updated on: February 01,2024

Researchers develop novel gold-nanocluster-based tumor radiodynamic therapy

by Zhang Nannan,Chinese Academy of SciencesGold-nanocluster-based radiodynamic therapy. Credit: IGDBRadiotherapy (RT) is a primary method of tumor treatment. However, in clinical practice, radio

Updated on:February 01,2024

Researchers advance CRISPR technology to replicate human diseases with unprecedented accuracy

by Walter and Eliza Hall Institute of Medical ResearchGeneration and validation of pdCas9a-SAM construct in Eµ-Myc lymphoma cell lines. a Schematic representation of the pdCas9a-SAM lentiviral co

Updated on: February 03,2024

Researchers advance CRISPR technology to replicate human diseases with unprecedented accuracy

by Walter and Eliza Hall Institute of Medical ResearchGeneration and validation of pdCas9a-SAM construct in Eµ-Myc lymphoma cell lines. a Schematic representation of the pdCas9a-SAM lentiviral co

Updated on:February 03,2024

Killing pancreatic cancer with T cells that supercharge themselves

by University of California, San FranciscoTherapeutic T cells engineered with tumor-triggered IL-2 production infiltrate and clear immune-excluded tumors. (A) We hypothesized that cell autonomous

Updated on: February 18,2024

Killing pancreatic cancer with T cells that supercharge themselves

by University of California, San FranciscoTherapeutic T cells engineered with tumor-triggered IL-2 production infiltrate and clear immune-excluded tumors. (A) We hypothesized that cell autonomous

Updated on:February 18,2024

Preclinical study shows promise of systemic targeted therapy in a rare form of cancer

byVall d'Hebron Institute of OncologyTreatment with BRAF inhibitors reduces tumor cell proliferation in subcutaneous BRAFV600EPMP-PDX tumors without impacting in apoptosis. a–d) Mice b

Updated on: August 03,2024

Preclinical study shows promise of systemic targeted therapy in a rare form of cancer

byVall d'Hebron Institute of OncologyTreatment with BRAF inhibitors reduces tumor cell proliferation in subcutaneous BRAFV600EPMP-PDX tumors without impacting in apoptosis. a–d) Mice b

Updated on:August 03,2024

Study shows novel agent can overcome immune dysfunction in cancer

by Roswell Park Comprehensive Cancer CenterVSSP restores myeloid cell frequencies following leukopenia. C57BL/6 mice were injected with CY (200 mg/kg body weight, i.p.) and with two consecutive daily

Updated on: January 22,2024

Study shows novel agent can overcome immune dysfunction in cancer

by Roswell Park Comprehensive Cancer CenterVSSP restores myeloid cell frequencies following leukopenia. C57BL/6 mice were injected with CY (200 mg/kg body weight, i.p.) and with two consecutive daily

Updated on:January 22,2024

The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia

by Justin Jackson , Medical XpressCohesin regulates alternative splicing. (A) Flowchart showing the experimental protocol, as detailed in Materials and Methods. (B) Schematic showing five different cl

Updated on: January 02,2024

The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia

by Justin Jackson , Medical XpressCohesin regulates alternative splicing. (A) Flowchart showing the experimental protocol, as detailed in Materials and Methods. (B) Schematic showing five different cl

Updated on:January 02,2024

Phobic anxiety is linked to sexuality issues in women who are breast cancer survivors

by University of CórdobaCredit: CC0 Public DomainA study carried out by a research team made up of researchers from the University of Cordoba, the Maimonides Institute of Biomedical Research (in Spani

Updated on: March 06,2024

Phobic anxiety is linked to sexuality issues in women who are breast cancer survivors

by University of CórdobaCredit: CC0 Public DomainA study carried out by a research team made up of researchers from the University of Cordoba, the Maimonides Institute of Biomedical Research (in Spani

Updated on:March 06,2024

Study discovers tumor monocyte content predicts immunochemotherapy outcomes for esophageal cancer

by Ludwig Institute for Cancer ResearchGraphical Abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.06.006A Ludwig Cancer Research study has discovered that the presence of

Updated on: February 01,2024

Study discovers tumor monocyte content predicts immunochemotherapy outcomes for esophageal cancer

by Ludwig Institute for Cancer ResearchGraphical Abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.06.006A Ludwig Cancer Research study has discovered that the presence of

Updated on:February 01,2024

Policies favoring high-volume hospitals may disadvantage rural cancer patients

by University of PittsburghCredit: Pixabay/CC0 Public DomainPatients with cancer who live in rural Pennsylvania counties appear to know that they may have better outcomes if they receive their ca

Updated on: February 03,2024

Policies favoring high-volume hospitals may disadvantage rural cancer patients

by University of PittsburghCredit: Pixabay/CC0 Public DomainPatients with cancer who live in rural Pennsylvania counties appear to know that they may have better outcomes if they receive their ca

Updated on:February 03,2024

Some cancer immunotherapy treatments may damage fertility

by Monash UniversityCredit: Pixabay/CC0 Public DomainResearchers have discovered that some immunotherapy treatments used to treat cancer can cause fertility damage.It means these treatments could

Updated on: January 30,2024

Some cancer immunotherapy treatments may damage fertility

by Monash UniversityCredit: Pixabay/CC0 Public DomainResearchers have discovered that some immunotherapy treatments used to treat cancer can cause fertility damage.It means these treatments could

Updated on:January 30,2024