Synthetic molecule proves able to mitigate heart failure in translational study

by Maria Fernanda Ziegler,FAPESPThe vicious cycle of heart failure (HF). (i) Impaired aldehyde metabolism by aldehyde dehydrogenase 2 (ALDH2); (ii) accumulation of 4-hydroxynonenal (4-HNE), a re

Updated on: April 01,2024

Synthetic molecule proves able to mitigate heart failure in translational study

by Maria Fernanda Ziegler,FAPESPThe vicious cycle of heart failure (HF). (i) Impaired aldehyde metabolism by aldehyde dehydrogenase 2 (ALDH2); (ii) accumulation of 4-hydroxynonenal (4-HNE), a re

Updated on:April 01,2024

Depression linked to deadly inflammation in lung cancer patients

by Jeff Grabmeier,The Ohio State UniversityKaplan Meier survival curve for NSCLC patients stratified by NLR systemic inflammation, NLR < 5 and NLR ≥ 5 (n = 184), showing worse survival probab

Updated on: January 30,2024

Depression linked to deadly inflammation in lung cancer patients

by Jeff Grabmeier,The Ohio State UniversityKaplan Meier survival curve for NSCLC patients stratified by NLR systemic inflammation, NLR < 5 and NLR ≥ 5 (n = 184), showing worse survival probab

Updated on:January 30,2024

Long-term collection of patient-reported outcome data in oncology trials: Important and feasible

by Institute for Quality and Efficiency in Health CareCredit: CC0 Public DomainPatient-reported outcome (PRO) data are collected in oncology trials to determine patients' perspectives of canc

Updated on: January 30,2024

Long-term collection of patient-reported outcome data in oncology trials: Important and feasible

by Institute for Quality and Efficiency in Health CareCredit: CC0 Public DomainPatient-reported outcome (PRO) data are collected in oncology trials to determine patients' perspectives of canc

Updated on:January 30,2024

Scientist identifies gene responsible for spread of prostate cancer

by Caitlin Coyle,Rutgers UniversityAntonina Mitrofanova is a pioneer in the emerging field of biomedical informatics, fighting cancer with big data. Credit: Nick RomanenkoA Rutgers study has fou

Updated on: March 06,2024

Scientist identifies gene responsible for spread of prostate cancer

by Caitlin Coyle,Rutgers UniversityAntonina Mitrofanova is a pioneer in the emerging field of biomedical informatics, fighting cancer with big data. Credit: Nick RomanenkoA Rutgers study has fou

Updated on:March 06,2024

Protein could offer therapeutic target for pancreatic cancer

by The Francis Crick InstituteHuman pancreatic ductal adenocarcinoma showing high levels of CD9 (red). Credit: Francis Crick InstituteA protein that drives growth of pancreatic cancer, and which

Updated on: March 01,2024

Protein could offer therapeutic target for pancreatic cancer

by The Francis Crick InstituteHuman pancreatic ductal adenocarcinoma showing high levels of CD9 (red). Credit: Francis Crick InstituteA protein that drives growth of pancreatic cancer, and which

Updated on:March 01,2024

Study: Drugs reprogram genes in breast tumors to prevent endocrine resistance

by Sharita Forrest,University of Illinois at Urbana-ChampaignTargeting estrogen receptor-positive breast tumors with the XPO1 antagonist selinexor and the tamoxifen byproduct 4-OHT simultaneousl

Updated on: May 27,2024

Study: Drugs reprogram genes in breast tumors to prevent endocrine resistance

by Sharita Forrest,University of Illinois at Urbana-ChampaignTargeting estrogen receptor-positive breast tumors with the XPO1 antagonist selinexor and the tamoxifen byproduct 4-OHT simultaneousl

Updated on:May 27,2024

Intraventricular immunovirotherapy: A translational step forward

by Impact JournalsPutative mechanisms of toxicity. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28343A new research perspective titled "Intraventricular immunovirotherapy; a tran

Updated on: January 02,2024

Intraventricular immunovirotherapy: A translational step forward

by Impact JournalsPutative mechanisms of toxicity. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28343A new research perspective titled "Intraventricular immunovirotherapy; a tran

Updated on:January 02,2024

Care at high-volume radiation treatment centers tied to higher survival

by Lori SolomonAmong men with very high-risk prostate cancer, higher radiation facility case volume is independently associated with longer overall survival, according to a study published online Aug.

Updated on: February 01,2024

Care at high-volume radiation treatment centers tied to higher survival

by Lori SolomonAmong men with very high-risk prostate cancer, higher radiation facility case volume is independently associated with longer overall survival, according to a study published online Aug.

Updated on:February 01,2024

New promising targeted drug for a rare leukemia

by University of HelsinkiBCL-2 family gene expression in blasts across AML types at single cell resolution. (A) UMAP plot of scRNA-seq data of blasts from AML with megakaryoblastic differentiatio

Updated on: February 18,2024

New promising targeted drug for a rare leukemia

by University of HelsinkiBCL-2 family gene expression in blasts across AML types at single cell resolution. (A) UMAP plot of scRNA-seq data of blasts from AML with megakaryoblastic differentiatio

Updated on:February 18,2024

New imaging technology for diagnosing and treating bowel cancer patients

byUniversity of GlasgowRepresentative transverse PET images from each mouse model and tracer. Credit:Clinical Cancer Research(2024). DOI: 10.1158/1078-0432.CCR-23-1063Biopsies are cu

Updated on: March 30,2024

New imaging technology for diagnosing and treating bowel cancer patients

byUniversity of GlasgowRepresentative transverse PET images from each mouse model and tracer. Credit:Clinical Cancer Research(2024). DOI: 10.1158/1078-0432.CCR-23-1063Biopsies are cu

Updated on:March 30,2024

Why a promising breast cancer drug doesn't work—and how to improve it

by Katherine Fenz,Rockefeller UniversityER-mediated transcriptional resistance to BD inhibition. Credit:Nature Structural & Molecular Biology(2024). DOI: 10.1038/s41594-024-01384

Updated on: September 28,2024

Why a promising breast cancer drug doesn't work—and how to improve it

by Katherine Fenz,Rockefeller UniversityER-mediated transcriptional resistance to BD inhibition. Credit:Nature Structural & Molecular Biology(2024). DOI: 10.1038/s41594-024-01384

Updated on:September 28,2024

Better adenoma detection using a molecular marker for fluorescent imaging

by Sarah E. Glass,Vanderbilt University(a)Representative white light and corresponding fluorescence colonoscopy images (static) of B6;129 mice bearing either colorectal adenomas or normal

Updated on: February 18,2024

Better adenoma detection using a molecular marker for fluorescent imaging

by Sarah E. Glass,Vanderbilt University(a)Representative white light and corresponding fluorescence colonoscopy images (static) of B6;129 mice bearing either colorectal adenomas or normal

Updated on:February 18,2024