Study in mice shows alterations in X-chromosome inactivation predispose female mammals to autoimmune disease

by Bob Yirka , Medical XpressPerturbation of X-inactivation in immune cells ofFtx−/−females.(A) Map of the X inactivation center showing the location ofXist(green) andFtx

Immunology & Rheumatology May 30,2024

Study in mice shows alterations in X-chromosome inactivation predispose female mammals to autoimmune disease

by Bob Yirka , Medical XpressPerturbation of X-inactivation in immune cells ofFtx−/−females.(A) Map of the X inactivation center showing the location ofXist(green) andFtx

Immunology & Rheumatology May 30,2024

CRISPR-based mapping uncovers 'switches' for immune genes central to health

byGladstone InstitutesTiling CRISPRi screens map gene-specific CREs across the costimulatory locus. Credit:Nature Genetics(2024). DOI: 10.1038/s41588-024-01743-5Healthy T cells are t

Breakthroughs May 30,2024

CRISPR-based mapping uncovers 'switches' for immune genes central to health

byGladstone InstitutesTiling CRISPRi screens map gene-specific CREs across the costimulatory locus. Credit:Nature Genetics(2024). DOI: 10.1038/s41588-024-01743-5Healthy T cells are t

Breakthroughs May 30,2024

Scientists leverage machine learning to decode gene regulation in the developing human brain

byGladstone InstitutesMassively parallel characterization and prediction of gene regulatory activity in the developing brain. Credit:Science(2024). DOI: 10.1126/science.adh0559In a s

Neurology May 30,2024

Scientists leverage machine learning to decode gene regulation in the developing human brain

byGladstone InstitutesMassively parallel characterization and prediction of gene regulatory activity in the developing brain. Credit:Science(2024). DOI: 10.1126/science.adh0559In a s

Neurology May 30,2024

Tracking the cellular and genetic roots of neuropsychiatric disease

byYale UniversityCredit: Pixabay/CC0 Public DomainA new analysis has revealed detailed information about genetic variation in brain cells that could open new avenues for the targeted treatment o

Psychiatry & Mental Health May 30,2024

Tracking the cellular and genetic roots of neuropsychiatric disease

byYale UniversityCredit: Pixabay/CC0 Public DomainA new analysis has revealed detailed information about genetic variation in brain cells that could open new avenues for the targeted treatment o

Psychiatry & Mental Health May 30,2024

Study uncovers cell type-specific genetic insights underlying schizophrenia

byMcLean HospitalCredit: CC0 Public DomainSchizophrenia is a complex disease with variable presentations, and the diverse nature of this mental health disorder has made understanding the mechani

Psychiatry & Mental Health May 30,2024

Study uncovers cell type-specific genetic insights underlying schizophrenia

byMcLean HospitalCredit: CC0 Public DomainSchizophrenia is a complex disease with variable presentations, and the diverse nature of this mental health disorder has made understanding the mechani

Psychiatry & Mental Health May 30,2024

Sequencing of the developing human brain uncovers hundreds of thousands of new gene transcripts

byUniversity of California, Los AngelesCredit: Unsplash/CC0 Public DomainA team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-iso

Neurology May 30,2024

Sequencing of the developing human brain uncovers hundreds of thousands of new gene transcripts

byUniversity of California, Los AngelesCredit: Unsplash/CC0 Public DomainA team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-iso

Neurology May 30,2024

Century-old vaccine found to protect type 1 diabetics from infectious diseases

byMassachusetts General HospitalGraphical abstract. Credit:iScience(2024). DOI: 10.1016/j.isci.2024.109881In new research, investigators at Massachusetts General Hospital (MGH) show

Diabetes & Endocrinology May 30,2024

Century-old vaccine found to protect type 1 diabetics from infectious diseases

byMassachusetts General HospitalGraphical abstract. Credit:iScience(2024). DOI: 10.1016/j.isci.2024.109881In new research, investigators at Massachusetts General Hospital (MGH) show

Diabetes & Endocrinology May 30,2024

Exposure to endocrine-disrupting chemicals in utero associated with higher odds of metabolic syndrome in children

byBarcelona Institute for Global HealthCredit: CC0 Public DomainThe term 'metabolic syndrome' (MetS) encompasses a group of factors, such as abdominal obesity, hypertension and insulin r

OB & GYN May 30,2024

Exposure to endocrine-disrupting chemicals in utero associated with higher odds of metabolic syndrome in children

byBarcelona Institute for Global HealthCredit: CC0 Public DomainThe term 'metabolic syndrome' (MetS) encompasses a group of factors, such as abdominal obesity, hypertension and insulin r

OB & GYN May 30,2024

Study suggests optogenetics can drive muscle contraction with greater control, less fatigue than electrical stimulation

byMassachusetts Institute of TechnologyMIT researchers have developed a way to help people with amputation or paralysis regain limb control. Instead of using electricity to stimulate muscles, th

Neurology May 30,2024

Study suggests optogenetics can drive muscle contraction with greater control, less fatigue than electrical stimulation

byMassachusetts Institute of TechnologyMIT researchers have developed a way to help people with amputation or paralysis regain limb control. Instead of using electricity to stimulate muscles, th

Neurology May 30,2024

Adhesive hydrogel coating prevents scarring around medical implants, prolongs lifespan of such devices

by Anne Trafton,Massachusetts Institute of TechnologyCredit: Pixabay/CC0 Public DomainWhen medical devices such as pacemakers are implanted in the body, they usually provoke an immune response t

Dermatology May 30,2024

Adhesive hydrogel coating prevents scarring around medical implants, prolongs lifespan of such devices

by Anne Trafton,Massachusetts Institute of TechnologyCredit: Pixabay/CC0 Public DomainWhen medical devices such as pacemakers are implanted in the body, they usually provoke an immune response t

Dermatology May 30,2024