Largest-ever genetic study of epilepsy finds possible therapeutic targets

by Ari Navetta,Broad Institute of MIT and HarvardEpilepsy genetic architecture from large-scale genetic association studies. Credit:Nature Neuroscience(2024). DOI: 10.1038/s41593-024

Neurology October 09,2024 0

Largest-ever genetic study of epilepsy finds possible therapeutic targets

by Ari Navetta,Broad Institute of MIT and HarvardEpilepsy genetic architecture from large-scale genetic association studies. Credit:Nature Neuroscience(2024). DOI: 10.1038/s41593-024

Neurology October 09,2024 0

Unveiling genetic insights: How PAI-1 polymorphisms influence COVID-19 outcomes

by Juntendo University Research Promotion CenterPAI-1 genetic variations impact blood clotting and inflammation in COVID-19, potentially guiding personalized treatments. Credit: Dr. Beate Heissig from

Epidemiology & Public Health October 09,2024 0

Unveiling genetic insights: How PAI-1 polymorphisms influence COVID-19 outcomes

by Juntendo University Research Promotion CenterPAI-1 genetic variations impact blood clotting and inflammation in COVID-19, potentially guiding personalized treatments. Credit: Dr. Beate Heissig from

Epidemiology & Public Health October 09,2024 0

Study reveals key role of TRIO gene in epileptic encephalopathies

byUniversity of MontrealDefective migration of MGE-derived cortical INs inTrio–/–embryos. Credit:Molecular Psychiatry(2024). DOI: 10.1038/s41380-024-02742-yWhat are the m

Neurology October 09,2024 0

Study reveals key role of TRIO gene in epileptic encephalopathies

byUniversity of MontrealDefective migration of MGE-derived cortical INs inTrio–/–embryos. Credit:Molecular Psychiatry(2024). DOI: 10.1038/s41380-024-02742-yWhat are the m

Neurology October 09,2024 0

Genetic variants linked to Alzheimer's trigger brain inflammation in females, preclinical study finds

byWeill Cornell Medical CollegeInflammatory microglia from afemalebrainin amouse model ofAlzheimer's disease. The mice also carry the APOE4 and TREM2 genetic ri

Neurology October 09,2024 0

Genetic variants linked to Alzheimer's trigger brain inflammation in females, preclinical study finds

byWeill Cornell Medical CollegeInflammatory microglia from afemalebrainin amouse model ofAlzheimer's disease. The mice also carry the APOE4 and TREM2 genetic ri

Neurology October 09,2024 0

Comprehensive mapping of genetic activity brings hope to patients with chronic pain

by Felicia Lindberg,Karolinska InstitutetTemporal molecular dynamics of nociceptors and pain states during neuropathic pain. Credit:Nature Communications(2024). DOI: 10.1038/s41467-0

Anesthesiology & Pain October 09,2024 0

Comprehensive mapping of genetic activity brings hope to patients with chronic pain

by Felicia Lindberg,Karolinska InstitutetTemporal molecular dynamics of nociceptors and pain states during neuropathic pain. Credit:Nature Communications(2024). DOI: 10.1038/s41467-0

Anesthesiology & Pain October 09,2024 0

Live-cell model system can decode genetic risk for psychiatric disorders

byUniversity of North Carolina at Chapel Hill School of MedicineGene regulatory changes induced by Wnt stimulation.a, Cartoon of the canonical Wnt signaling pathway.b, Schematic of s

Psychiatry October 09,2024 0

Live-cell model system can decode genetic risk for psychiatric disorders

byUniversity of North Carolina at Chapel Hill School of MedicineGene regulatory changes induced by Wnt stimulation.a, Cartoon of the canonical Wnt signaling pathway.b, Schematic of s

Psychiatry October 09,2024 0

Research explores genetic treatment for rare arrhythmias

by Albert McKeon,Children's Hospital BostonCredit: CC0 Public DomainVariants in a gene that plays a key role in heart function can cause potentially life-threatening arrhythmia syndromes kno

Cardiology & Vascular surgery October 09,2024 0

Research explores genetic treatment for rare arrhythmias

by Albert McKeon,Children's Hospital BostonCredit: CC0 Public DomainVariants in a gene that plays a key role in heart function can cause potentially life-threatening arrhythmia syndromes kno

Cardiology & Vascular surgery October 09,2024 0

New genomic surveillance tools could help efforts to eliminate damaging parasitic infections

byWashington University in St. LouisOverview of experiments and analysis. (a) Brugia malayi experiments. Adult worms collected from an experimental host (gerbils) and microfilariae of a known pe

Epidemiology & Public Health October 09,2024 0

New genomic surveillance tools could help efforts to eliminate damaging parasitic infections

byWashington University in St. LouisOverview of experiments and analysis. (a) Brugia malayi experiments. Adult worms collected from an experimental host (gerbils) and microfilariae of a known pe

Epidemiology & Public Health October 09,2024 0

Scientists uncover genetic cause of rare autoimmune disorder

by Olivia Dimmer,Northwestern UniversityCredit: Unsplash/CC0 Public DomainA team of international scientists has uncovered the genetic underpinnings of a rare, inherited autoimmune disorder, acc

Reproduction October 09,2024 0

Scientists uncover genetic cause of rare autoimmune disorder

by Olivia Dimmer,Northwestern UniversityCredit: Unsplash/CC0 Public DomainA team of international scientists has uncovered the genetic underpinnings of a rare, inherited autoimmune disorder, acc

Reproduction October 09,2024 0

AI promises to ramp up PCR tests for faster DNA diagnostics and forensics

byFlinders UniversityDiagrammatic explanation of the firefly algorithm used to suggest new PCR programs in this study. Credit:Genes(2024). DOI: 10.3390/genes15091199Promising new inr

Reproduction October 09,2024 0

AI promises to ramp up PCR tests for faster DNA diagnostics and forensics

byFlinders UniversityDiagrammatic explanation of the firefly algorithm used to suggest new PCR programs in this study. Credit:Genes(2024). DOI: 10.3390/genes15091199Promising new inr

Reproduction October 09,2024 0