Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Breakthroughs March 28,2024

Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Breakthroughs March 28,2024

Study eases concern at antipsychotics use in pregnancy

byUniversity of New South WalesCrude and propensity score-weighted cumulative incidence (with 95% confidence intervals) for composite neurodevelopmental outcome from age 3–19 years in children o

Breakthroughs March 28,2024

Study eases concern at antipsychotics use in pregnancy

byUniversity of New South WalesCrude and propensity score-weighted cumulative incidence (with 95% confidence intervals) for composite neurodevelopmental outcome from age 3–19 years in children o

Breakthroughs March 28,2024

CBD products don't ease pain and are potentially harmful, study finds

by Vittoria D'Alessio,University of BathCredit: Unsplash/CC0 Public DomainThere is no evidence that CBD products reduce chronic pain, and taking them is a waste of money and potentially harm

Breakthroughs March 28,2024

CBD products don't ease pain and are potentially harmful, study finds

by Vittoria D'Alessio,University of BathCredit: Unsplash/CC0 Public DomainThere is no evidence that CBD products reduce chronic pain, and taking them is a waste of money and potentially harm

Breakthroughs March 28,2024

FDA approves oral Duvyzat for Duchenne muscular dystrophy

by Lori SolomonThe U.S. Food and Drug Administration has approved Duvyzat (givinostat) as an oral medication for the treatment of Duchenne muscular dystrophy (DMD) in patients six years of age and old

Breakthroughs March 28,2024

FDA approves oral Duvyzat for Duchenne muscular dystrophy

by Lori SolomonThe U.S. Food and Drug Administration has approved Duvyzat (givinostat) as an oral medication for the treatment of Duchenne muscular dystrophy (DMD) in patients six years of age and old

Breakthroughs March 28,2024

ABT199/Venetoclax synergism with thiotepa in acute myeloid leukemia (AML) cells

by Impact Journals LLCEffects of various drug combinations on molecular markers of apoptosis in patient-derived cell samples. Credit:Oncotarget(2024). DOI: 10.18632/oncotarget.28563A new r

Breakthroughs March 28,2024

ABT199/Venetoclax synergism with thiotepa in acute myeloid leukemia (AML) cells

by Impact Journals LLCEffects of various drug combinations on molecular markers of apoptosis in patient-derived cell samples. Credit:Oncotarget(2024). DOI: 10.18632/oncotarget.28563A new r

Breakthroughs March 28,2024

Medicare to cover Wegovy when patients also have heart disease

by Robin FosterMedicare will now cover the popular weight-loss drug Wegovy if patients using it also have heart disease, U.S. officials announced Thursday.The move comes after the U.S. Food and Drug A

Breakthroughs March 28,2024

Medicare to cover Wegovy when patients also have heart disease

by Robin FosterMedicare will now cover the popular weight-loss drug Wegovy if patients using it also have heart disease, U.S. officials announced Thursday.The move comes after the U.S. Food and Drug A

Breakthroughs March 28,2024

Atezolizumab addition to chemotherapy after surgery does not improve survival for triple negative breast cancer: Study

by European Organisation for Research and Treatment of CancerCredit: Unsplash/CC0 Public DomainPatients with triple-negative breast cancer do not benefit from the addition of atezolizumab to their pos

Breakthroughs March 28,2024

Atezolizumab addition to chemotherapy after surgery does not improve survival for triple negative breast cancer: Study

by European Organisation for Research and Treatment of CancerCredit: Unsplash/CC0 Public DomainPatients with triple-negative breast cancer do not benefit from the addition of atezolizumab to their pos

Breakthroughs March 28,2024

Researchers pinpoint issue that could be hampering common chemotherapy drug

by Anika Hazra,University of TorontoGenome-wide CRISPR–Cas9 screens reveal modulators of gemcitabine sensitivity. Credit:Nature Cancer(2024). DOI: 10.1038/s43018-024-00742-zResearche

Breakthroughs March 28,2024

Researchers pinpoint issue that could be hampering common chemotherapy drug

by Anika Hazra,University of TorontoGenome-wide CRISPR–Cas9 screens reveal modulators of gemcitabine sensitivity. Credit:Nature Cancer(2024). DOI: 10.1038/s43018-024-00742-zResearche

Breakthroughs March 28,2024

Choosing over the counter drugs for COVID 19? It's complicated

byFlorida Atlantic UniversityResearchers take a closer look at both the potential benefits and risks of acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs)—such as ibuprofen, as well a

Breakthroughs March 28,2024

Choosing over the counter drugs for COVID 19? It's complicated

byFlorida Atlantic UniversityResearchers take a closer look at both the potential benefits and risks of acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs)—such as ibuprofen, as well a

Breakthroughs March 28,2024

Mimicking exercise with a pill

byAmerican Chemical SocietyCredit: Unsplash/CC0 Public DomainDoctors have long prescribed exercise to improve and protect health. In the future, a pill may offer some of the same benefits as exe

Breakthroughs March 28,2024

Mimicking exercise with a pill

byAmerican Chemical SocietyCredit: Unsplash/CC0 Public DomainDoctors have long prescribed exercise to improve and protect health. In the future, a pill may offer some of the same benefits as exe

Breakthroughs March 28,2024