Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Breakthroughs March 14,2024

Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Breakthroughs March 14,2024

Large-scale study explores link between smoking and DNA changes across six racial and ethnic groups

by Zara Abrams,Keck School of Medicine of USCCredit: CC0 Public DomainSmoking changes the way genes are expressed, which later contributes to the development of lung cancer and other smoking-rel

Breakthroughs March 14,2024

Large-scale study explores link between smoking and DNA changes across six racial and ethnic groups

by Zara Abrams,Keck School of Medicine of USCCredit: CC0 Public DomainSmoking changes the way genes are expressed, which later contributes to the development of lung cancer and other smoking-rel

Breakthroughs March 14,2024

Danish study could pave the way for better diagnosis of rare genetic diseases

byAarhus UniversityGraphical abstract. Credit:The American Journal of Human Genetics(2024). DOI: 10.1016/j.ajhg.2023.12.024There are over 7,000 different rare genetic diseases, and o

Breakthroughs March 14,2024

Danish study could pave the way for better diagnosis of rare genetic diseases

byAarhus UniversityGraphical abstract. Credit:The American Journal of Human Genetics(2024). DOI: 10.1016/j.ajhg.2023.12.024There are over 7,000 different rare genetic diseases, and o

Breakthroughs March 14,2024

Predicting neurodevelopmental disease in children from parents' traits

by Sam Sholtis,Pennsylvania State UniversityNeurodevelopmental and psychiatric disorders, and the genes that can lead to them, vary in a population (left, brighter red colors represent more seve

Breakthroughs March 14,2024

Predicting neurodevelopmental disease in children from parents' traits

by Sam Sholtis,Pennsylvania State UniversityNeurodevelopmental and psychiatric disorders, and the genes that can lead to them, vary in a population (left, brighter red colors represent more seve

Breakthroughs March 14,2024

Zebrafish's eye muscles give hope for people with muscular dystrophy diseases

by Claes Björnberg,Umea UniversityAxon and NMJ integrity is partially rescued by overexpression of fhl2b in trunk muscle of 5 dpf dmd-/-zebrafish larvae. Credit: https://umu.diva-portal.or

Breakthroughs March 14,2024

Zebrafish's eye muscles give hope for people with muscular dystrophy diseases

by Claes Björnberg,Umea UniversityAxon and NMJ integrity is partially rescued by overexpression of fhl2b in trunk muscle of 5 dpf dmd-/-zebrafish larvae. Credit: https://umu.diva-portal.or

Breakthroughs March 14,2024

'Eat, sleep, console' reduces hospital stay and need for medication among opioid-exposed infants

by NIH/Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentCredit: Pixabay/CC0 Public DomainResearchers have found the "Eat, Sleep, Console" (ESC) care approa

Pediatrics March 14,2024

'Eat, sleep, console' reduces hospital stay and need for medication among opioid-exposed infants

by NIH/Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentCredit: Pixabay/CC0 Public DomainResearchers have found the "Eat, Sleep, Console" (ESC) care approa

Pediatrics March 14,2024

Meta-analysis of ACE inhibitor–induced angioedema identifies novel risk locus in genome

by Petra Sandow,University Hospital BonnManhattan plot of the metaEURanalysis. The −log10association P values (vertical axis) for all variants of the metaEURanalysis against th

Breakthroughs March 14,2024

Meta-analysis of ACE inhibitor–induced angioedema identifies novel risk locus in genome

by Petra Sandow,University Hospital BonnManhattan plot of the metaEURanalysis. The −log10association P values (vertical axis) for all variants of the metaEURanalysis against th

Breakthroughs March 14,2024

Genetic risk prediction for ten chronic diseases moves closer to the clinic

byBroad Institute of MIT and HarvardCredit: CC0 Public DomainBy analyzing millions of small genetic differences across a person's genome, researchers can calculate a polygenic risk score to

Genetics March 14,2024

Genetic risk prediction for ten chronic diseases moves closer to the clinic

byBroad Institute of MIT and HarvardCredit: CC0 Public DomainBy analyzing millions of small genetic differences across a person's genome, researchers can calculate a polygenic risk score to

Genetics March 14,2024

4.7 percent of students with disabilities experience homelessness

by Elana GotkineOverall, 4.7 percent of students with disabilities experience homelessness across seven states and Washington D.C., according to a study published online March 28 inPediatrics.Em

Pediatrics March 14,2024

4.7 percent of students with disabilities experience homelessness

by Elana GotkineOverall, 4.7 percent of students with disabilities experience homelessness across seven states and Washington D.C., according to a study published online March 28 inPediatrics.Em

Pediatrics March 14,2024

Type 1 diabetes: First clinical trial of GABA/GAD in newly diagnosed, very young children

by Jeff Hansen,University of Alabama at BirminghamGlycemic control in study groups over time. Glycosylated Hemoglobin (HbA1c) (a) and insulin adjusted A1c (IDAA1c) (b) were measured in the three

Pediatrics March 14,2024

Type 1 diabetes: First clinical trial of GABA/GAD in newly diagnosed, very young children

by Jeff Hansen,University of Alabama at BirminghamGlycemic control in study groups over time. Glycosylated Hemoglobin (HbA1c) (a) and insulin adjusted A1c (IDAA1c) (b) were measured in the three

Pediatrics March 14,2024